Alprazolam

Papers

1. Alprazolam: a review of its pharmacodynamic properties and efficacy in the treatment of anxiety and depression Dawson, G.W., et al. Drugs 27, 132-47, (1984)

2. An Overview of the CNS-Pharmacodynamic Profiles of Nonselective and Selective GABA Agonists Chen, X., et al. Adv. Pharmacol. Sci. 2012, 1-10, (2012)

Mouse strains differ in their sensitivity to alprazolam effect in the staircase test. Weizman, R., et al. Brain Res. 839, 58-65, (1999)

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Effects of alprazolam on the free-choice ethanol consumption induced by isolation stress in aged rats. Nunez, M.J., et al. Life Sci. 64, PL213-PL217, (1999)

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Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Yong-Hua Wang et al Bioorg. Med. Chem. Lett. 15, 4076-84, (2005)

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Molecular characteristics for solid-state limited solubility. Carola M Wassvik et al J. Med. Chem. 51, 3035-9, (2008)

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Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Michael H Abraham et al Eur. J. Med. Chem. 43, 478-85, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Yun W Alelyunas et al Bioorg. Med. Chem. Lett. 20, 7312-6, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Panagis Filippakopoulos et al Bioorg. Med. Chem. 20, 1878-86, (2012)

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Merck 14,312