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  • A8842 - Anti-Amyloid Precursor Protein, KPI Domain antibody produced in rabbit

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A8842 Sigma

Anti-Amyloid Precursor Protein, KPI Domain antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-APP

Properties

Related Categories AM-AN, Alphabetical Index, Antibodies, Antibodies for Alzheimer′s Disease, Antibodies for Neurobiology,
species reactivity   mouse, human, rat
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using formic acid-treated sections of human Alzheimer′s disease (AD) brain
  microarray: suitable
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... APP(351)
mouse ... App(11820)
rat ... App(54226)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the Kunitz Protease Inhibitor (KPI) domain of human APP770 (amino acids 301-315) conjugated to KLH.

General description

Amyloid precursor proteins (APPs) are transmembrane glycoproteins that are found in a wide range of tissues. APPs have 3 main isoforms, namely, APP695, APP751 and APP770 that are derived from alternative splicing events in cells. Accumulation of the cleavage products of APP, such as the β-amyloid peptide, can cause Alzheimer′s disease.

The immunogen sequence is identical in rat and mouse APP770 and in the APP isoform APP751, and is absent in APP695. By immunohistochemistry, the antibody recognizes APP770.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Rabbit Anti-Amyloid Precursor Protein, KPI Domain antibody has been used for immunohistochemistry assays at 1:500. The product can also be used for microarrays.

Price and Availability

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