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A9043 Sigma

S-Acetylthioglycolic acid N-hydroxysuccinimide ester

≥95% (TLC), powder

Synonym: N-Succinimidyl (acetylthio)acetate, N-Succinimidyl S-acetylthioglycolate, S-Acetylthioglycolic acid NHS ester, SATA

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Properties

Related Categories Building Blocks, Chemical Synthesis, Crosslinking, Heterobifunctional Cross-Linking Reagents, Molecular Biology,
InChI Key   FLCQLSRLQIPNLM-UHFFFAOYSA-N
assay   ≥95% (TLC)
form   powder
solubility   acetonitrile: soluble50 mg/mL
  DMF: soluble
storage temp.   −20°C

Description

Application

Thiolating reagent for primary amines; thiol can be deprotected under mild conditions. Typically, couples initially to a molecule containing primary amine by amide bond buffered at pH 7.5. Deprotection may be accomplished with 0.05 M hydroxylamine at neutral pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.

Other Notes

Note that the ester couples very efficiently to primary amines compared to other thiolating reagents. In addition, this reagent will neutralize original amine positive charge.

Packaging

10, 50, 100 mg in glass bottle

Price and Availability


Amplified Detection
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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