A9525 Sigma

Angiotensin II human

≥93% (HPLC), powder


Related Categories Angiotensins, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
assay   ≥93% (HPLC)
form   powder
impurities   1.2-10.4% acetate
storage temp.   −20°C
Gene Information   human ... AGT(183)


Amino Acid Sequence


Antibody Adsorbant

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH3COOH · H2O

Analysis Note

Peptide content not less than 75%

Biochem/physiol Actions

Angiotensin (Ang) II is important in regulating cardiovascular hemodynamics and cardiovascular structure. Most of the known effects of Ang II in adult tissues are attributable to the angiotensin II type I (AT1) receptor. The AT1 and AT2 receptors have differential pharmacological and biochemical properties and appear to exert opposite effects in terms of cardiovascular hemodynamics and cell growth. In addition, the renin-angiotensin and nitric oxide-generating systems appear to interract in the regulation of cardiovascular function. Ang II stimulates angiogenesis and increases microvessel density. In nature, angiotensin II is produced by the action of angiotensin converting enzyme on angiotensinogen; the C-terminal-His-Leu is cleaved.

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