|Related Categories||Angiotensins, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,|
|Gene Information||human ... AGT(183)|
Peptide content not less than 75%
Angiotensin (Ang) II is important in regulating cardiovascular hemodynamics and cardiovascular structure. Most of the known effects of Ang II in adult tissues are attributable to the angiotensin II type I (AT1) receptor. The AT1 and AT2 receptors have differential pharmacological and biochemical properties and appear to exert opposite effects in terms of cardiovascular hemodynamics and cell growth. In addition, the renin-angiotensin and nitric oxide-generating systems appear to interract in the regulation of cardiovascular function. Ang II stimulates angiogenesis and increases microvessel density. In nature, angiotensin II is produced by the action of angiotensin converting enzyme on angiotensinogen; the C-terminal-His-Leu is cleaved.
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Different receptors/binding sites have been identified for the biologically active angiotensin (Ang) peptides, i.e. Ang II (1-8), Ang III (2-8), Ang IV (3-8) and Ang (1-7), based on the availability ...
Keywords: Atomic absorption spectroscopy, Cardiovascular, Catalysis, Cell proliferation, Gene expression, Ligands, Metabolites, Transduction
Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions
Obesity is a well-established risk factor for the development of insulin resistance. Obesity is associated with the increased deposition of lipids in non-adipose tissue with subsequent decreases in i...
Linda Stephenson, Ph.D.
Biofiles v6 n4, 9
Keywords: Angiogenesis, Antivirals, Apoptosis, Biological processes, Cardiovascular, Catalysis, Cell culture, Cell proliferation, Deposition, Diabetes, Gene expression, Growth factors, Hormones, Inflammation, Metabolism, Metabolites, Obesity, Phosphorylations, Physiological Processes, Reductions, Transcription, Transduction
The term "neuropeptidases" refers to those enzymes that participate in the inactivation of synaptically released neuropeptides and therefore serve to turn off the generated peptide signal. In general...
Keywords: AGE, Alzheimer Disease, Angiogenesis, Anti-inflammatory agents, Cancer, Cardiovascular, Cell proliferation, Degradations, Diabetes, Digestions, Gene expression, Hormones, Inflammation, Metabolism, Neurotransmitters, Normal-phase chromatography, Obesity, Respiratory, Schizophrenia, Sequencing
Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Gas chromatography
Cross talk between angiotensin II type 1 and type 2 receptors: cellular mechanism of angiotensin type 2 receptor-mediated cell growth inhibition. Xoriuchi, M., et al. Hypertens. Res. 22, 67-74, (1999)
Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Takeshige, K., et al. Circulation 114, 953-960, (2006)
Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype. Cheng, C., et al. Atherosclerosis 204, 26-33, (2009)
Pharmacodynamic And Pharmacokinetic Characterization Of The Aldosterone Synthase Inhibitor FAD286 In Two Rodent Models Of Hyperaldosteronism: Comparison With The 11beta-hydroxylase Inhibitor Metyrapone. Rigel, D.F., et al. J. Nutr. 334, 232-43, (2010)
Activation of Src mediates PDGF-induced Smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis. Mima A, Abe H, Nagai K, et al. PLoS ONE 6(3), e17929, (2011)
Angiotensin II inhibits ADH-stimulated cAMP: role on O2- and transport-related oxygen consumption in the loop of Henle. Silva GB, Juncos LI, Baigorria ST, et al. J. Biol. Regul. Homeost. Agents 27(2), 569-78, (2013)
The effect of high-fructose intake on the vasopressor response to angiotensin II and adrenergic agonists in Sprague-Dawley rats. Abdulla MH, Sattar MA, Abdullah NA, et al. Pak. J. Pharm. Sci. 26(4), 727-32, (2013)
Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice. Ju X, Ijaz T, Sun H, et al. Arterioscler. Thromb. Vasc. Biol. 33(7), 1612-21, (2013)
The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers. Wilson PC, Lee MH, Appleton KM, et al. J. Biol. Chem. 288(26), 18872-84, (2013)
Nitric oxide-angiotensin II interactions and renal hemodynamic function in patients with uncomplicated type 1 diabetes. Montanari A, Pelà G, Musiari L, et al. Am. J. Physiol. Renal Physiol. 305(1), F42-51, (2013)
Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation. Tanaka S, Fukumoto Y, Nochioka K, et al. Arterioscler. Thromb. Vasc. Biol. 33(7), 1591-600, (2013)
White blood cell count in women: relation to inflammatory biomarkers, haematological profiles, visceral adiposity, and other cardiovascular risk factors. Farhangi MA, Keshavarz SA, Eshraghian M, et al. J. Health. Popul. Nutr. 31(1), 58-64, (2013)
Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension. Zhang W, Zhang Y, Wang W, et al. Circ. Res. 112(11), 1466-78, (2013)
Nifedipine inhibits angiotensin II-induced cardiac fibrosis via downregulating Nox4-derived ROS generation and suppressing ERK1/2, JNK signaling pathways. Jia Y, Xu J, Yu Y, et al. Pharmazie 68(6), 435-41, (2013)
Relative atrial natriuretic peptide deficiency and inadequate renin and angiotensin II suppression in obese hypertensive men. Asferg CL, Nielsen SJ, Andersen UB, et al. Hypertension 62(1), 147-53, (2013)
Pinocembrin inhibits angiotensin II-induced vasoconstriction via suppression of the increase of [Ca2+]i and ERK1/2 activation through blocking AT(1)R in the rat aorta. Li L, Pang XB, Chen BN, et al. Biochem. Biophys. Res. Commun. 435(1), 69-75, (2013)
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