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A9789 Sigma

Anisomycin from Streptomyces griseolus

≥98% (HPLC), solid

Synonym: (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin

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Properties

Related Categories AN-AZ, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application,
InChI Key   YKJYKKNCCRKFSL-RDBSUJKOSA-N
Quality Level   PREMIUM
assay   ≥98% (HPLC)
form   solid
color   white to faint yellow
solubility   H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.)
  DMSO: 20 mg/mL
  methanol: 20 mg/mL
Mode of action   protein synthesis | interferes
storage temp.   2-8°C

Description

Caution

Hygroscopic

Packaging

5, 25, 100 mg in glass bottle

Biochem/physiol Actions

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGIII
WGK Germany 
3
RTECS 
BZ9800000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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