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A9981 Sigma

Monoclonal Anti-AP-2α antibody produced in mouse

~1.0 mg/mL, clone AP2a 8G8/5, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-AP-2α, Anti-AP-2, Anti-AP2TF, Anti-TFAP2, Anti-TFAP2A

Properties

Related Categories AA - CA, AO-AQ, Alphabetical Index, Antibodies, Antibodies to Common Transcription Factors,
species reactivity   human
application(s)   immunohistochemistry: suitable
  western blot: 1-2 μg/mL using SK-Mel 19 total cell extract
clone   AP2a 8G8/5, monoclonal
concentration   ~1.0 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
mol wt   antigen mol wt ~50 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TFAP2A(7020)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

human AP-2α/AP-2γ fusion protein.

General description

Adaptor protein-2 (AP2) is a key constituent of clathrin-coated vesicles that mediate the endocytosis of cell membrane components such as G protein-coupled receptors (GPCRs). AP2 is a heterotetramer that consists of α, β, μ and σ subunits which bind to tyrosine- and dileucine-based motifs on membrane-associated cargo proteins.
Mouse Monoclonal Anti-AP-2α antibody binds to human AP-2α.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Immunoprecipitation and western blot analysis was performed on virally -infected A549 cells using monoclonal mouse anti-AP-2 IgG (clone 100/2).

Mouse Monoclonal Anti-AP-2α antibody can be used for western blot (1-2μg/ml) and IHC assays.

Price and Availability


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