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B0313 Sigma

Anti-BCS1L (96-110) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-BCS1, Anti-BCS, Anti-BJS, Anti-FLNMS, Anti-GRACILE, Anti-PTD



Related Categories Alphabetical Index, Antibodies, B-BI, Primary Antibodies
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~48 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... BCS1L(617)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 96-110 of human BCS1L

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Anti-BCS1L (96-110) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:2000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

BCS1L gene encodes a single-pass membrane protein, which is a cellular homologue of Saccharomyces cerevisiae bcs1 protein and is localized in the mitochondrion inner membrane. It plays a crucial role in the assembly of mitochondrial respiratory chain complex III. The encoded protein also facilitates the mitochondrial tubular network′s maintenance as well as LETM1 complex formation. Additionally, BCS1L also assist in neural structures development during ontogenesis in mice. Point mutation in BCS1L gene results in GRACILE (growth retardation, aminoaciduria, cholestasis, iron overload, lactacidosis, and early death) syndrome associated with abnormalities in iron metabolism.

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

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