|Related Categories||Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors,|
|solubility||H2O: soluble15 mg/mL, clear|
|Gene Information||human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)|
Inhibits the dopamine and norepinephrine transporters with Kis of 2.8 μM and 1.4 μM, respectively. Does not inhibit the serotonin transporter (Ki = 45 μM). Antidepressant.
Certificate of Analysis
Certificate of Origin
Following vesicular release, the biogenic amine neurotransmitters, norepinephrine (A7257), dopamine (H8502) and serotonin (H9523), are removed from the extracellular space by selective and pharmacolo...
Bupropion and desipramine increase dopamine transporter mRNA expression in the ventral tegmental area/substantia nigra of rat brain. Petrie, E.C., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 22, 845, (1998)
Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo. Cooper, B.R., et al. J. Pharmacol. Exp. Ther. 215, 127-134, (1980)
Treatment of tobacco use in lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Leone FT, Evers-Casey S, Toll BA, et al. Chest 143(5 Suppl), e61S-77S, (2013)
Effects of varenicline and bupropion sustained-release use plus intensive smoking cessation counseling on prolonged abstinence from smoking and on depression, negative affect, and other symptoms of nicotine withdrawal. Cinciripini PM, Robinson JD, Karam-Hage M, et al. JAMA Psychiatry 70(5), 522-33, (2013)
Rapid assessment of cardiovascular risk among users of smoking cessation drugs within the US Food and Drug Administration's Mini-Sentinel program. Toh S, Baker MA, Brown JS, et al. JAMA Intern. Med. 173(9), 817-9, (2013)
Comparison of the effectiveness of varenicline and combination nicotine replacement therapy for smoking cessation in clinical practice. Brose LS, West R, and Stapleton JA Mayo Clin. Proc. 88(3), 226-33, (2013)
Augmentation of venlafaxine with bupropion: risks associated with a triple monoamine reuptake inhibition approach to partially responsive depression. Andrade C J. Clin. Psychiatry 74(2), e119-21, (2013)
Quantitative electroencephalogram biomarkers for predicting likelihood and speed of achieving sustained remission in major depression: a report from the biomarkers for rapid identification of treatment effectiveness in major depression (BRITE-MD) trial. Cook IA, Hunter AM, Gilmer WS, et al. J. Clin. Psychiatry 74(1), 51-6, (2013)
Bupropion for smoking cessation in patients hospitalized with acute myocardial infarction: a randomized, placebo-controlled trial. Eisenberg MJ, Grandi SM, Gervais A, et al. J. Am. Coll. Cardiol. 61(5), 524-32, (2013)
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits. Carvalho MM, Campos FL, Coimbra B, et al. Molecular Neurodegeneration 8, 14, (2013)
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