Synonym: 8-Br-cGMP, 8-Bromo-cyclic GMP
|Related Categories||B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism,|
|solubility||H2O: soluble50 mg/mL|
Cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase. Slows or inhibits the intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine. Reported to mimic the effect of nitric oxide generating drugs.
Customers Also Viewed
~95% (HPLC), powder
≥97% (HPLC), powder
Certificate of Analysis
Certificate of Origin
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Francis, S.H., et al. Mol. Pharmacol. 34, 506-517, (1988)
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. Garg, U.C., and Hassid, A. J. Clin. Invest. 83, 1774-1777, (1989)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?