Synonym: 8-Br-cGMP, 8-Bromo-cyclic GMP
|Related Categories||B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism,|
|solubility||H2O: soluble50 mg/mL|
Cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase. Slows or inhibits the intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine. Reported to mimic the effect of nitric oxide generating drugs.
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Cyclic AMP-dependent protein kinase (PKA or cAK) and cyclic GMP-dependent protein kinase (PKG or cGK) transfer the γ-phosphate of ATP to serine and threonine residues of many cellular proteins. PKAs ...
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Francis, S.H., et al. Mol. Pharmacol. 34, 506-517, (1988)
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. Garg, U.C., and Hassid, A. J. Clin. Invest. 83, 1774-1777, (1989)
Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Yang J, Li X, Al-Lamki RS, et al. Arterioscler. Thromb. Vasc. Biol. 33(1), 34-42, (2013)
Endothelial dysfunction enhances the pulmonary and systemic vasodilator effects of phosphodiesterase-5 inhibition in awake swine at rest and during treadmill exercise. Houweling B, Quispel J, Beier N, et al. Exp. Biol. Med. (Maywood.) 237(2), 201-10, (2012)
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction. Glaza I, Szadujkis-Szadurski L, Szadujkis-Szadurski R, et al. Postepy Hig. Med. Dosw. (Online) 65, 496-500, (2011)
Neutrophil beta2 integrin inhibition by enhanced interactions of vasodilator-stimulated phosphoprotein with S-nitrosylated actin. Thom SR, Bhopale VM, Yang M, et al. J. Biol. Chem. 286(37), 32854-65, (2011)
Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats. Yen DH, Chen LC, Shen YC, et al. J. Biomed. Sci. 18, 32, (2011)
Effect of nitric oxide on epithelial ion transports in noncystic fibrosis and cystic fibrosis human proximal and distal airways. Blouquit-Laye S, Dannhoffer L, Braun C, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 303(7), L617-25, (2012)
Involvement of Na+/K+ pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field. Nikolić L, Todorović N, Zakrzewska J, et al. J. Comp. Physiol. A. Neuroethol. Sens. Neural. Behav. Physiol. 198(7), 525-40, (2012)
Nitric oxide synthase activity in the abdominal aorta of rats is decreased after 4 weeks of simulated microgravity. Ren XL, Zhang R, Zhang YY, et al. Clin. Exp. Pharmacol. Physiol. 38(10), 683-7, (2011)
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