8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
≥98% (HPLC), powder
DOWNLOAD MSDS (PDF)Synonym: 8-Br-cGMP, 8-Bromo-cyclic GMP
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CAS Number 51116-01-9
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Empirical Formula (Hill Notation) C10H10BrN5NaO7P
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Molecular Weight 446.08
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EC Number 256-993-8
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MDL number MFCD00070128
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PubChem Substance ID 24278021
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Popular Documents: Product Information Sheet (PDF) | Specification Sheet (PDF)
Properties
| Related Categories | B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, |
| assay | ≥98% (HPLC) |
| form | powder |
| solubility | H2O: soluble50 mg/mL |
| storage temp. | −20°C |
Description
Biochem/physiol Actions
Cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase. Slows or inhibits the intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine. Reported to mimic the effect of nitric oxide generating drugs.
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