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B1401 Sigma

Bradykinin Fragment 1-5

≥97% (HPLC)

  • CAS Number 23815-89-6

  • Empirical Formula (Hill Notation) C27H40N8O6

  • Molecular Weight 572.66

  •  MDL number MFCD00076260

  •  PubChem Substance ID 24891591

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Properties

Related Categories Bradykinins, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,
InChI Key   USSUMSBPLJWFSZ-UHFFFAOYSA-N
assay   ≥97% (HPLC)
storage temp.   −20°C
Gene Information   human ... KNG1 (includes EG:3827)(3827)

Description

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

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Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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