|Related Categories||Antagonists, B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,|
human ... EDNRA(1909), EDNRB(1910)|
rat ... Ednra(24326), Ednrb(50672)
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Selective ETA endothelin receptor antagonist.
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Endothelins are a family of vasoactive peptides that were discovered in a search for the identity of a vasoconstricting factor known to exist in the media from cultured endothelial cells. The first m...
The endothelin ETA receptor antagonist BQ-123 normalizes the response of SHR aorta to Ca2+ channel activator. Morel, et al. Eur. J. Pharmacol. 252, (1994)
Extracellular signal-regulated kinases 1/2 signaling pathways are not involved in endothelin regulation of mouse inner medullary collecting duct nitric oxide production. Hyndman KA, MacDonell AH, and Pollock JS Life Sci. 91(13-14), 578-82, (2012)
Role of endothelin-A receptors in optic nerve head red cell flux regulation during isometric exercise in healthy humans. Boltz A, Schmidl D, Werkmeister RM, et al. Am. J. Physiol. Heart Circ. Physiol. 304(1), H170-4, (2013)
Taming the "sleeping giant": the role of endothelin-1 in the regulation of skeletal muscle blood flow and arterial blood pressure during exercise. Barrett-O'Keefe Z, Ives SJ, Trinity JD, et al. Am. J. Physiol. Heart Circ. Physiol. 304(1), H162-9, (2013)
Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation. Tonari M, Kurimoto T, Horie T, et al. Invest. Ophthalmol. Vis. Sci. 53(7), 3490-500, (2012)
Systemic endothelin receptor blockade in ST-segment elevation acute coronary syndrome protects the microvasculature: a randomised pilot study. Adlbrecht C, Andreas M, Redwan B, et al. EuroIntervention 7(12), 1386-95, (2012)
Assessment of endothelin-A receptor expression in subcutaneous and orthotopic thyroid carcinoma xenografts in vivo employing optical imaging methods. Büther K, Compeer MG, De Mey JG, et al. Endocrinology 153(6), 2907-18, (2012)
Antenatal betamethasone has a sex-dependent effect on the in vivo response to endothelin in adult sheep. Lee JH, Zhang J, Flores L, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304(8), R581-7, (2013)
Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia. Piechota-Polańczyk A and Gorąca A Pharmacol. Rep. 64(6), 1434-41, (2012)
Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome. Schinzari F, Tesauro M, Rovella V, et al. J. Clin. Endocrinol. Metab. 98(3), 1235-41, (2013)
Endothelin-1 acutely reduces the permeability of visceral sheep peritoneum in vitro through both endothelin-A and endothelin-B receptors. Kourti P, Zarogiannis SG, Liakopoulos V, et al. Artif. Organs 37(3), 308-12, (2013)
The influence of ETA and ETB receptor blockers on LPS-induced oxidative stress and NF-κB signaling pathway in heart. Piechota-Polanczyk A, Kleniewska P, and Gorąca A Gen. Physiol. Biophys. 31(3), 271-8, (2012)
Pharmacological differences of endothelin receptors-mediated modulation in cultured interstitial cells of Cajal from the murine small and large intestine. Kim BJ, Chang IY, and So I Cell Physiol. Biochem. 30(2), 359-71, (2012)
Fluorescence correlation spectroscopy in drug discovery: study of Alexa532-endothelin 1 binding to the endothelin ETA receptor to describe the pharmacological profile of natural products. Caballero-George C, Sorkalla T, Jakobs D, et al. ScientificWorldJournal 2012, 524169, (2012)
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