|Related Categories||Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,|
Fluorimetric substrate for cytochrome P450-linked enzymes.
Certificate of Analysis
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-36|
Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues...
Biofiles Volume 6 Article 1
Keywords: Catalysis, Eliminations, Environmental, Enzyme-linked immunosorbent assay, Gastrointestinal, Gene expression, Immunohistochemistry, Metabolism, Metabolites, Oxidations, Post translational modifications, Reductions, Western blot
Inhibition against mosquito cytochrome P450 enzymes by rhinacanthin-A, -B, and -C elicits synergism on cypermethrin cytotoxicity in Spodoptera frugiperda cells. Pethuan S, Duangkaew P, Sarapusit S, et al. J. Med. Entomol. 49(5), 993-1000, (2012)
Tertiary butyl alcohol in drinking water induces phase I and II liver enzymes with consequent effects on thyroid hormone homeostasis in the B6C3F1 female mouse. Blanck O, Fowles J, Schorsch F, et al. J. Appl. Toxicol. 30(2), 125-32, (2010)
Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Sun L, Chen CS, Waxman DJ, et al. Arch. Biochem. Biophys. 458(2), 167-74, (2007)
Functional characterization of medaka CYP3A38 and CYP3A40: kinetics and catalysis by expression in a recombinant baculovirus system. Kashiwada S, Hinton DE, and Kullman SW Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 141(4), 338-48, (2005)
Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix. Scott EE, Liu H, Qun He Y, et al. Arch. Biochem. Biophys. 423(2), 266-76, (2004)
Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Nerurkar, P.V., et al. Biochem. Pharmacol. 46, 933, (1993)
Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat. Nims RW, McClain RM, Manchand PS, et al. J. Pharmacol. Exp. Ther. 270(1), 348-55, (1994)
Distribution of cytochrome P450 activities towards alkoxyresorufin derivatives in rat brain regions, subcellular fractions and isolated cerebral microvessels. Perrin R, Minn A, Ghersi-Egea JF, et al. Biochem. Pharmacol. 40(9), 2145-51, (1990)
Identification of in vitro cytochrome P450 modulators to detect induction by prototype inducers in the mallard duckling (Anas platyrhynchos). Renauld AE, Melancon MJ, and Sordillo LM Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. 122(2), 273-81, (1999)
Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues. He YQ, Szklarz GD, and Halpert JR Arch. Biochem. Biophys. 335(1), 152-60, (1996)
Hepatic cytochrome P450 and related drug biotransformation during an outbreak of mouse hepatitis virus in a colony of Swiss BALB/c mice. Armstrong S and Renton KW Can. J. Physiol. Pharmacol. 71(2), 188-90, (1993)
Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy. Meehan RR, Forrester LM, Stevenson K, et al. Biochem. J. 254(3), 789-97, (1988)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?