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B1938 Sigma

Anti-BNIP2 (424-435) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-Bcl-2/adenovirus E1B 19kD interacting protein 2, Anti-BNIP-2, Anti-NIP2



Related Categories Alphabetical Index, Antibodies, BL-BZ, Primary Antibodies
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~49 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... BNIP2(663)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 424-435 of human BNIP2

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Anti-BNIP2 (424-435) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

BNIP2 gene encodes a protein which is the binding partner of the adenovirus anti-apoptotic protein, E1B-19K and its cellular homologue, BCL2. It consists of the IEAD motif close to the N-terminus which is highly conserved in vertebrate and is a known granzyme B cleavage site in mammalian BNIP-2 proteins. BNIP2 possess pro-apoptotic activity and is a substrate for caspase, which makes it a granzyme B target during human natural killer cell-mediated killing. Moreover, BNIP2 interacts with Cdc42 via its BCH domain and initiates cell elongation and membrane protrusions.

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

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