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B2313 Sigma

Anti-BPI (256-270) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-Bactericidal permeability-increasing protein precursor



Related Categories Alphabetical Index, Antibodies, BL-BZ, Primary Antibodies
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~54 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... BPI(671)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 256-270 of human BPI

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Anti-BPI (256-270) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

BPI gene encodes a 50-60-kD membrane associated bactericidal permeability increasing protein mapped on to chromosome 20q11.23. It may contain two domains:- the amino-terminal domain contains large fraction of basic and hydrophilic residues whereas carboxyl-terminal domain consist of more acidic than basic residues. BPI protein is associated with human neutrophil granules and possesses high affinity for lipopolysaccharide. It has antimicrobial activity against gram-negative organisms and is essential constituent of the innate immune system for destroying the microbes as well as modulates subsequent adaptive immune responses. Mutation in BPI gene or a decrease of plasma BPI level may leads to chronic obstructive pulmonary disease.

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

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