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B2430 Sigma

Monoclonal Anti-Betacellulin antibody produced in mouse

clone 34362.11, purified immunoglobulin, lyophilized powder

Synonym: Anti-BTC

Description

Immunogen

recombinant human betacellulin (BTC)

General description

βcellulin (BTC) is a growth factor that belongs to the epidermal growth factor (EGF) family. BTC is the product of post-translational modification of a larger membrane-anchored precursor peptide. A wide range of tissues including liver, kidney, pancreas and small intestine highly express BTC. The main function of BTC is the regulation of growth, proliferation, regeneration and differentiation of pancreatic β cells. It also has important physiological role in the development and function of endocrine precursor cells of pancreas. The cellular effects of BTC are mediated by the EGF receptors, Erb-1, -2, -3 and -4. The pathways mediated by the binding of BTC to Erbs are Ras/MAPK and PI3K pathways. βcellulin has been reported to also drive proliferation of osteoblasts and neural stem cells and increase cortical bone deposition and neurogenesis, respectively
Monoclonal Anti-βcellulin (BTC) recognizes human βcellulin. This antibody exhibits no cross-reactivity with recombinant human EGF, HB-EGF, TGF-a, HRG-a, and AR in immunoblotting.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Preparation Note

Purified using protein A.

Application

Anti-βcellulin antibody may be used for immunoblotting at a working concentration of 1.0-2.0 μg/ml. The antibody is suitable for ELISA at a recommended concentration of 1-2 μg/ml.

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