B2434 Sigma

Bleomycin sulfate from Streptomyces verticillus

BioXtra, crystalline

Synonym: Blenoxane, Bleo, Blexane

Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal,
product line   BioXtra
form   crystalline
potency   1.5-2.0 units per mg
solubility   H2O: soluble20 mg/mL, clear, colorless
cation traces   Cu: ≤0.10%
suitability   suitable for cell culture
storage temp.   2-8°C

Description

Application

Recommended for use as a selection agent at 10-100 μg/ml.

Bleomycin is used as a transformed cell selection agent, especially for plant transformants. Recommended for use at 10-100 g/ml. It is also used to induce pulmonary fibrosis and epithelial cell apoptosis. 1,2,3

Biochem/physiol Actions

An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



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