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B3436 Sigma

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide

≥98% (HPLC), solid

Synonym: C2-8

  • CAS Number 300670-16-0

  • Empirical Formula (Hill Notation) C19H14Br2N2O3S

  • Molecular Weight 510.20

  •  MDL number MFCD00355835

  •  PubChem Substance ID 24724418

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology
InChI Key   SJJKUNDBFWUAQB-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   off-white
solubility   DMSO: ~20 mg/mL
  H2O: insoluble
storage temp.   2-8°C

Description

Biochem/physiol Actions

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

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