EMAIL THIS PAGE TO A FRIEND

B3503 Sigma

Benzidine

≥98.0% (N)

Synonym: 4,4′-Diaminobiphenyl

Purchase

Properties

Related Categories B, Cell Biology, Hematology and Histology, Stains & Dyes, A to Z, Stains and Dyes More...
assay   ≥98.0% (N)
Gene Information   human ... UGT1A4(54657)

Description

Biochem/physiol Actions

Initiates tumors in the bladder under experimental conditions.1

Application

Benzidine (4,4′-Diaminobiphenyl) is an environmental genotoxin that posses increased risks of cancer to exposed people. Benzidine may be used as a reference material in procedures that analyze for benzidine. Benzidine can be used in studies on its mechanisms of genotoxicity.

Price and Availability

TruPAGE™ Pre-cast Polyacrylamide Gels


TruPAGE™ Pre-cast Polyacrylamide GelsTruPAGE Gels run true every time!

  • . 2-Year Shelf Life
  • . Superior Band Resolution
  • . Strong & Tear Resistant
  • . Higher Capacity Wells


Customers Also Viewed

Benzidine

ISOPAC®, ≥98.0% (N)

Benzidine

analytical standard

Benzidine

purum p.a., ≥98.0% (N)

Benzidine dihydrochloride

≥99% (titration)

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Hazard Codes (Europe) 
T,N
Risk Statements (Europe) 
Safety Statements (Europe) 
53-45-60-61
RIDADR 
UN 1885 6.1 / PGII
WGK Germany 
3
RTECS 
DC9625000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

Related Content

Carcinogen Selector - Digestive System - Liver

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Digestive System - Liver
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System - Liver Endocrine

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Liver Endocrine
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System - Mammary Gland

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Mammary Gland
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Hematopoietic System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Hematopoietic System
Keywords: Cancer, Carcinogens, Respiratory

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. Benzidine: a bladder carcinogen. Wendel, R.G. et al. J. Urol. 111, 607-610, (1974)

Loading...


pH-operated nanopistons on the surfaces of mesoporous silica nanoparticles. Zhao YL, Li Z, Kabehie S, et al. J. Am. Chem. Soc. 132(37), 13016-25, (2010)

Loading...


Occupational allergic contact dermatitis and patch test results of leather workers at two Indonesian tanneries. Febriana SA, Jungbauer F, Soebono H, et al. Contact Dermatitis 67(5), 277-83, (2012)

Loading...


Amine functional monodisperse microbeads via precipitation polymerization of N-vinyl formamide: immobilized laccase for benzidine based dyes degradation. Karagoz B, Bayramoglu G, Altintas B, et al. Bioresour. Technol. 102(13), 6783-90, (2011)

Loading...


Distinct Functions For The Glycans Of Tapasin And Heavy Chains In The Assembly Of MHC Class I Molecules. Rizvi, S.M., et al. J. Immunol. 186, 2309-20, (2011)

Loading...


N-Acetyltransferase 2 genotype, exfoliated urothelial cells and benzidine exposure Ma, Q.W., et al. Front. Biosci. 4, 1966-74, (2012)

Bladder cancer, a review of the environmental risk factors. Letašiová S, Medve'ová A, Šovčíková A, et al. Environ. Health Perspect. 11, S11, (2012)

Occupational contact allergy caused by benzidine in three tannery workers. Febriana SA, Jungbauer F, Soebono H, et al. Contact Dermatitis 66, 345-346, (2012)

Loading...


N-Acetyltransferase 2 genotype, exfoliated urothelial cells and benzidine exposure. Ma QW, Lin GF, Chen JG, et al. Front. Biosci. (Elite Ed.) 4, 1966-74, (2012)

Loading...


Superparamagnetic Fe3O4 nanoparticles-carbon nitride nanotube hybrids for highly efficient peroxidase mimetic catalysts. Lee JW, Jeon HJ, Shin HJ, et al. Chem. Commun. (Camb.) 48(3), 422-4, (2012)

Loading...


Induction of DNA damage signaling genes in benzidine-treated HepG2 cells. Ching Chen S, Hseu YC, Sung JC, et al. Environ. Mol. Mutagen. 52, 664-672, (2011)

Loading...


Removal of benzidine from polluted water by soluble and immobilized peroxidase in batch processes and continuous horizontal bed reactor. Karim Z and Husain Q Environ. Technol. 32(1-2), 83-91, (2011)

Loading...


Reverse phase protein microarrays: fluorometric and colorimetric detection. Gallagher RI, Silvestri A, Petricoin EF, et al. Methods Mol. Biol. 723, 275-301, (2011)

Loading...


Evaluation of peroxidase activity by α-naphthol/pyronine staining compared with benzidine staining in 101 acute leukemia cases. Latger-Cannard V, Bardet V, et al. Lab. Hematol. 16, 76-82, (2010)

Loading...


Biological activity resulting from exposure to aquatic environmental genotoxic pollutants in northern Egypt. Saad AA, El-Sikaily AM, Kholeif SF, et al. East. Mediterr. Health J. 16(1), 82-8, (2010)

Loading...


From monomers to π stacks, from nonconductive to conductive: syntheses, characterization, and crystal structures of benzidine radical cations. Chen X, Ma B, Wang X, Yao S, Ni L, et al. Chemistry 18, 11828-11836, (2012)

Loading...


High response organic deep ultraviolet photodetector with PEDOT:PSS anode. Zhu L, Dai Q, Hu ZF, et al. Optics Letters 36(10), 1821-3, (2011)

Loading...


Synthesis of carbazoles by intramolecular arylation of diarylamide anions. Budén ME, Vaillard VA, Martin SE, et al. J. Org. Chem. 74(12), 4490-8, (2009)

Loading...


In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

Loading...


Methods for the enhancement of fingermarks in blood. Bossers LC, Roux C, Bell M, et al. Forensic Sci. Int. 210(1-3), 1-11, (2011)

Loading...


Human health perspectives on environmental exposure to benzidine: a review. Choudhary G Chemosphere 32(2), 267-91, (1996)

Loading...


Visual observation of the mercury-stimulated peroxidase mimetic activity of gold nanoparticles. Long YJ, Li YF, Liu Y, et al. Chem. Commun. (Camb.) 47(43), 11939-41, (2011)

Loading...


N-glucuronidation of benzidine and its metabolites. Role in bladder cancer. Zenser TV, Lakshmi VM, and Davis BB Drug Metab. Dispos. 26(9), 856-9, (1998)

Loading...


Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

Loading...


The fabrication of high density nanochannel organic light emitting diodes with reduced charge spreading. Trivedi K, Bhansali US, Gnade B, et al. Nanotechnology 20(40), 405204, (2009)

Loading...


Transfer of occupational health problems from a developed to a developing country: lessons from the Japan-South Korea experience. Park J, Hisanaga N, and Kim Y Am. J. Ind. Med. 52(8), 625-32, (2009)

Loading...


Effect of presumptive tests reagents on human blood confirmatory tests and DNA analysis using real time polymerase chain reaction. de Almeida JP, Glesse N, and Bonorino C Forensic Sci. Int. 206(1-3), 58-61, (2011)

Loading...


The genetic and environmental factors involved in benzidine metabolism and bladder carcinogenesis in exposed workers. Carreón T, LeMasters GK, Ruder AM, et al. Front. Biosci. 11, 2889-902, (2006)

Loading...


Effects of ethanol and phenobarbital on hemoglobin adducts formation in rats exposed to benzidine and Direct Black 38. Kim KY, Roh JH, Lee SH, et al. Ind. Health 47(4), 383-92, (2009)

Loading...


Genotypic and phenotypic biomarker profiles for individual risk assessment and cancer detection (lessons from bladder cancer risk assessment in symptomatic patients and workers exposed to benzidine). Hemstreet GP and Wang W Front. Biosci. 9, 2671-9, (2004)

Loading...


Benzidine mechanistic data and risk assessment: species- and organ-specific metabolic activation. Whysner J, Verna L, and Williams GM Pharmacol. Ther. 71(1-2), 107-26, (1996)

Loading...


Benzidine: mechanisms of oxidative activation and mutagenesis. Josephy PD Fed. Proc. 45(10), 2465-70, (1986)

Loading...


Electrochemically grown imprinted polybenzidine nanofilm on multiwalled carbon nanotubes anchored pencil graphite fibers for enantioselective micro-solid phase extraction coupled with ultratrace sensing of d- and l-methionine. Prasad BB, Srivastava A, Pandey I, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 912, 65-74, (2013)

Loading...


Cancer incidence and mortality among workers exposed to benzidine. Brown SC, Alberts R, and Schoenberg M Am. J. Ind. Med. 54(4), 300-6, (2011)

Loading...


Mechanisms of oxidative DNA damage induced by carcinogenic arylamines. Murata M and Kawanishi S Front. Biosci. (Landmark Ed.) 16, 1132-43, (2011)

Loading...


Cellular proliferation, cell death, and liver histology in Gambusia affinis after dietary exposure to benzidine and 2-aminofluorene. Lentz S, Eversole R, Law JM, et al. Int. J. Toxicol. 29(3), 247-58, (2010)

Loading...


Occupational reproductive function abnormalities and bladder cancer in Korea. Park J, Shin KS, and Kim Y J. Korean Med. Sci. 25(Suppl), S41-5, (2010)

Loading...


Merck 14,1077

Beil. 13,IV,364

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?