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B4186 Sigma

Butyrylcholinesterase from human serum

vial of ≥5 units

Synonym: Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase

Description

Frequently Asked Questions

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Analysis Note

Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surfaceantigen, and Hepatitis C antibodies.

Unit Definition

One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.

Application

Butyrylcholinesterase (BChE) may be used to hydrolyze large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates. BchE may be used to treat organophosphate toxicity. It may be a useful tool in Alzheimer’s research. BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds 1.

Biochem/physiol Actions

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates.

Price and Availability

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