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B5002 Sigma

5-Bromo-2′-deoxyuridine

≥99% (HPLC)

Synonym: 5-BrdU, 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil, 5-Bromouracil deoxyriboside, BUdR

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Description

Frequently Asked Questions

Live Chat and Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

Thymidine analog used as a mutagen in genetic research. Selectively incorporated into cellular DNA during S-phase.

Packaging

1, 5, 100 g in glass bottle

100, 250, 500 mg in glass bottle

Application

5-Bromo-2′-deoxyuridine (5-BrdU) is a thymidine analogue which is incorporated into DNA. 5-BrdU is routinely and extensively used to measure DNA synthesis and to label dividing cells. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T
Risk Statements (Europe) 
Safety Statements (Europe) 
53-45
WGK Germany 
2
RTECS 
YU7350000

Protocols & Articles

Articles

Inhibition of Autoregulated TFG-ß

We studied autocrine transforming growth factor (TGF)beta signaling in kidney epithelium. Cultured proximal tubule cells showed regulated signaling that was high during log-phase growth, low during c...
Keywords: Growth factors

Peer-Reviewed Papers

References

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A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face. Hu D, Young NM, Li X, et al. Development 142(3), 567-74, (2015)

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DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Jacob V, Chernyavskaya Y, Chen X, et al. Development 142(3), 510-21, (2015)

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The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis. Zhang T, Murphy MW, Gearhart MD, et al. Development 141(19), 3662-71, (2014)

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Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Michailovici I, Harrington HA, Azogui HH, et al. Development 141(13), 2611-20, (2014)

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Ghrelin stimulates proliferation, migration and differentiation of neural progenitors from the subventricular zone in the adult mice. Li E, Kim Y, Kim S, et al. Exp. Neurol. 252, 75-84, (2014)

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MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex. Dudok JJ, Sanz AS, Lundvig DM, et al. J. Neurosci. 33(19), 8518-27, (2013)

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Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells. Cai L, Wang D, Fisher AL, et al. Biochem. Biophys. Res. Commun. 447(2), 292-8, (2014)

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Merck 14,1452

Beil. 24,IV,1234

Corp MSDS 1 (1), 519:B / FT-IR 1 (2), 816:C / FT-IR 2 (3), 3842:D / FT-NMR 1 (3), 375:A / IR-Spectra (3), 1357:C / IR-Spectra (2), 1182:A / NMR-Reference 2 (2), 695:B / RegBook 1 (2), 2571:C / Sax 6, 525 / Sigma FT-IR 1 (1), 763:B / Structure Index 1, 406:A:7

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