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  • B5050 - Monoclonal Anti-Brain-derived Neurotrophic Factor antibody produced in mouse

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B5050 Sigma

Monoclonal Anti-Brain-derived Neurotrophic Factor antibody produced in mouse

clone 35928.11, purified immunoglobulin, lyophilized powder

Synonym: Anti-BDNF

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8-25 μg/mL using human spinal cord
  western blot: 1-2 μg/mL
clone   35928.11, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG1
storage temp.   −20°C
Gene Information   human ... BDNF(627)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

Recombinant human BDNF, expressed in Sf 21 cells.

General description

The antibody shows ~5% cross-reactivity with recombinant human β−NGF and recombinant rat β−NGF.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified from ascites fluid using protein A.

Biochem/physiol Actions

Brain derived neurotrophic factor (BDNF) belongs to a family of secreted proteins called neurotrophins that includes, nerve growth factor (NGF), neurotrophin-3 (NT3) and NT4/5. BDNF is expressed in the developing and the mature brain. The downstream pathways promoted by BDNF include PI3K, MAPK and JAK/STAT. The most important role of BDNF is the regulation of synaptic transmission and plasticity, protein synthesis and phosphorylation of local proteins.

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