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B6179 Sigma

Bongkrekic acid solution

from Pseudomonas cocovenenans, ≥95% (HPLC), ~1 mg/mL



Biochem/physiol Actions

An antiapoptotic agent, it protects against NMDA receptor induced neuronal apoptosis,­ extends cell survival in cells undergoing apoptosis following infection with viral vectors and abrogates apoptosis induced by hydrogen peroxide in T-cells. It is an inhibitor of adenine nucleotide translocase, which is a component of the mitochondrial permeability transition (MPT) pore complex. Bongkrekic acid prevents mitochondrial depolarization, swelling, rupture of mitochondrial outer membrane, and release of apoptogenic proteins such as cytochrome c. This phenomenon was observed during staurosporine induced apoptosis in Jurkat cells, in HepG2 undergoing apoptosis following TNF-α and ethanol.

Other Notes

The toxic principle of P. cocovenenans.


0.5 mg in glass bottle

Physical form

Solution in 0.01 M Tris buffer, pH 7.5.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Biomedical Applications
Safety & Documentation

Safety Information

NONH for all modes of transport
Protocols & Articles


Discover Bioactive Small Molecules for Apoptosis

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Discover Bioactive Small Molecules for Cell Cycle Research

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