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B6312 Sigma

14-3-3 Beta histidine-tagged human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: 14-3-3 β, 14-3-3 protein Beta, GW128, HS1, KCIP-1 protein 1054, YWHAB

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cell Signaling and Neuroscience More...
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   buffered aqueous glycerol solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... YWHAB(7529)

Description

Physical form

Supplied as a 0.2 μm filtered solution in 50 mM Tris, pH 7.6, 1 mM EDTA, 1 mM DTT and 20% glycerol (w/v).

Biochem/physiol Actions

14-3-3 proteins are a multifunctional protein family comprising seven mammalian isoforms that interact with over two hundred different intracellular molecules including kinases, phosphatases, transcription factors, scaffold proteins, and DNA. 14-3-3 proteins are involved in a multitude of biological functions and play a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. 14-3-3 β participates in various processes, among which is the positive regulation of cell cycle progression and tumorigenesis. Over-expression of 14-3-3 β in NIH-3T3 cells confers tumorigenicity in nude mice via activation of the mitogen-activated protein kinase (MAPK) cascade.

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Flow Cytometry Instruments

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Protocols & Articles
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