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B6542 Sigma

Brefeldin A

≥99% (HPLC and TLC), BioXtra, for molecular biology

Synonym: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
Quality Level   PREMIUM
biological source   from Penicillium brefeldianum
grade   for molecular biology
InChI Key   KQNZDYYTLMIZCT-KQPMLPITSA-N
product line   BioXtra
assay   ≥99% (HPLC and TLC)
form   powder
solubility   DMSO: soluble10 mg/mL (Store stock solutions at -20 °C)
Mode of action   protein synthesis | interferes
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Principle

Brefeldin is a fungal metabolite that disrupts protein secretion in eukaryotic cells by disrupting the Golgi apparatus. It does not affect the process of protein synthesis.

Application

Suitable for molecular biology studies of secretory proteins and mechanisms of intracellular transport

Biochem/physiol Actions

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

General description

Brefeldin induces ADP-ribosylation of CtBP1/BARS protein that regulates the intracellular trafficking and movement of secretory proteins from endoplasmic reticulum to Golgi apparatus.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
GY8410000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Brefeldin A from Penicillium brefeldianum

CAS RN 20350-15-6 Sysnonyms: Decumbin; Ascotoxin; Cyanein; BFA; g,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4 cyclopentanecrotonic acid l-lactone Molecular formula: C16H24O4 Molecular weight: 280.36
Keywords: Absorption, Addition reactions, Cell culture, Centrifugation, Enzyme-linked immunosorbent assay, Ligands, Metabolites

Peer-Reviewed Papers
15

References

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