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B7263 Sigma

N-tert-Butyl-α-phenylnitrone

≥98% (GC)

Synonym: N-Benzylidene-tert-butylamine N-oxide, PBN, Phenyl N-t-butylnitrone

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Properties

Related Categories A to C, Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Cyclooxygenase,
InChI Key   IYSYLWYGCWTJSG-XFXZXTDPSA-N
assay   ≥98% (GC)
form   powder
color   white
mp   73-74 °C(lit.)
solubility   DMSO: soluble
storage temp.   −20°C

Description

Packaging

1, 5 g in glass bottle

Biochem/physiol Actions

N-tert-butyl-α-phenylnitrone (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy. The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100Å g).

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TX1760000
Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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