|Related Categories||Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|deionized water: insoluble|
human ... HBA2(3040), PPARA(5465), PPARD(5467), PPARG(5468)|
mouse ... Ppara(19013), Ppard(19015), Pparg(19016)
The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.
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Rosiglitazone and bezafibrate modulate gene expression in a rat model of non-alcoholic fatty liver disease--a historical prospective. Schmilovitz-Weiss H, Hochhauser E, Cohen M, et al. Lipids Health Dis. 12, 41, (2013)
Effects of bezafibrate treatment in a patient and a carrier with mutations in the PNPLA2 gene, causing neutral lipid storage disease with myopathy. van de Weijer T, Havekes B, Bilet L, et al. Circ. Res. 112(5), e51-4, (2013)
Square-wave voltammetric determination of bezafibrate in pharmaceutical formulations using a cathodically pretreated boron-doped diamond electrode. Ardila JA, Sartori ER, Rocha-Filho RC, et al. Talanta 103, 201-6, (2013)
Lymphocyte-suppressing effects of omega-3 fatty acids in bezafibrate-treated patients with isolated hypertriglyceridemia. Krysiak R, Gdula-Dymek A, and Okopien B Eur. J. Intern. Med. 23(6), e166-7, (2012)
Statin and fibrate combination does not additionally lower plasma cholesteryl ester transfer in type 2 diabetes mellitus. de Vries R, Dikkeschei BD, Sluiter WJ, et al. Clin. Lab. 58(11-12), 1231-9, (2012)
Phospholipase D activation mediates cobalamin-induced downregulation of Multidrug Resistance-1 gene and increase in sensitivity to vinblastine in HepG2 cells. Marguerite V, Gkikopoulou E, Alberto JM, et al. Int. J. Biochem. Cell Biol. 45(2), 213-20, (2013)
Simvastatin but not bezafibrate decreases plasma lipoprotein-associated phospholipase A₂ mass in type 2 diabetes mellitus: relevance of high sensitive C-reactive protein, lipoprotein profile and low-density lipoprotein (LDL) electronegativity. Constantinides A, de Vries R, van Leeuwen JJ, et al. Eur. J. Intern. Med. 23(7), 633-8, (2012)
Omega-3 fatty acids enhance monocyte-suppressing effect of bezafibrate in patients with isolated hypertriglyceridemia. Krysiak R, Gdula-Dymek A, and Okopien B Eur. J. Intern. Med. 23(7), e171-2, (2012)
Bezafibrate can be a new treatment option for mitochondrial fatty acid oxidation disorders: evaluation by in vitro probe acylcarnitine assay. Yamaguchi S, Li H, Purevsuren J, et al. Mol. Genet. Metab. 107(1-2), 87-91, (2012)
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