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B7283 Sigma

Benserazide hydrochloride

≥98% (TLC), solid

Synonym: DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride



Biochem/physiol Actions

Inhibitor of L-aromatic amino acid decarboxylase.

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Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Determination of Water Content in Benserazid hydrochloride Using Karl Fischer Titration

Group(s): Pharmaceutical Products + Compounds, Carboxylic Acid Derivatives, Nitrogen Compounds
Keywords: Indicators, Oxidations, Pharmaceutical, Titrations

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

Peer-Reviewed Papers


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Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice. Mango D, Bonito-Oliva A, Ledonne A, et al. Exp. Neurol. 261, 733-43, (2014)


Spinal cord injury enables aromatic L-amino acid decarboxylase cells to synthesize monoamines. Wienecke J, Ren LQ, Hultborn H, et al. J. Neurosci. 34(36), 11984-2000, (2014)


Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Dragicevic E, Poetschke C, Duda J, et al. Brain 137(Pt 8), 2287-302, (2014)


Noradrenergic terminals regulate L-DOPA-derived dopamine extracellular levels in a region-dependent manner in Parkinsonian rats. Navailles S, Milan L, Khalki H, et al. CNS Neurosci. Ther. 20(7), 671-8, (2014)


Genome-wide microarray analysis identifies a potential role for striatal retrograde endocannabinoid signaling in the pathogenesis of experimental L-DOPA-induced dyskinesia. Wang Y, Zhang QJ, Wang HS, et al. Synapse 68(8), 332-43, (2014)


Side effect profile of 5-HT treatments for Parkinson's disease and L-DOPA-induced dyskinesia in rats. Lindenbach D, Palumbo N, Ostock CY, et al. Br. J. Pharmacol. 172(1), 119-30, (2014)


RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease. Ko WK, Martin-Negrier ML, Bezard E, et al. Neurobiol. Dis. 70, 138-48, (2014)


L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum. Wang Y, Wang HS, Wang T, et al. J. Neurosci. Res. 92(12), 1733-45, (2014)


Merck 14,1050

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