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B7651 Sigma

Brefeldin A

from Penicillium brefeldianum, ≥99% (HPLC and TLC)

Synonym: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
Quality Level   PREMIUM
biological source   from Penicillium brefeldianum
assay   ≥99% (HPLC and TLC)
solubility   ethanol: soluble1-5 mg/mL (Store stock solutions at -20 °C.)
  DMSO: soluble10 mg/mL (Store stock solutions at -20 °C.)
  methanol: soluble10 mg/mL (Store stock solutions at -20 °C.)
Mode of action   protein synthesis | interferes
storage temp.   2-8°C

Description

Application

Brefeldin A has been shown to increase CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Brefeldin A has been shown to increase CRISPR-mediated homology-directed repair (HDR) efficiency.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
GY8410000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Small Molecule CRISPR Enhancers

As the CRISPR-Cas9 system has become an increasingly popular tool for genome editing, the desire to improve efficiency of precise CRISPR-mediated gene editing has arisen. A number of studies have ide...
Keywords: Bioactive small molecules, Chemical biology, Cyclizations, Genetic, Recombination, Transcription

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