Brefeldin A

Papers

Golgi-disturbing agents. Dinter, A. and Berger, E.G. Histochem. Cell Biol. 109, 571-590, (1998)

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Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. Linardic, C.M., et al. Cell Growth Differ. 7, 765-774, (1996)

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Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2. Guo, H., et al. Exp. Cell Res. 245, 57, (1998)

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Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53. Shao, R.G., et al. Exp. Cell Res. 227, 190-196, (1996)

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WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection. R. Alvarez et al J. Virol. 82, 471-86, (2008)

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Apoptotic cells induce dendritic cell-mediated suppression via interferon-γ-induced IDO. Charlotte A Williams et al Immunology 124, 89-101, (2008)

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Primary human immunodeficiency virus type 1-specific CD8+ T-cell responses induced by myeloid dendritic cells. Bonnie A. Colleton et al J. Virol. 83, 6288-99, (2009)

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D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague. Frank M. Szaba et al Infect. Immun. 77, 4295-304, (2009)

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Characterization of regulatory T cells identified as CD4(+)CD25(high)CD39(+) in patients with active tuberculosis. T Chiacchio et al Clin. Exp. Immunol. 156, 463-70, (2009)

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Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone) increases antibody response, cellular immunity, and antigenically drifted protection. Marla Lay et al Vaccine 27, 3811-20, (2009)

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Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation. A. Johnston et al Br. J. Dermatol. 159, 342-50, (2009)

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Treatment-dependent loss of polyfunctional CD8+ T-cell responses in HIV-infected kidney transplant recipients is associated with herpesvirus reactivation. O Gasser et al Am. J. Transplant. 9, 794-803, (2009)

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Co-engagement of α(4)β(1) integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells. Tae Kon Kim et al Hum. Immunol. 71, 23-8, (2009)

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αB-crystallin: a Golgi-associated membrane protein in the developing ocular lens. Rajendra K. Gangalum et al Invest. Ophthalmol. Vis. Sci. 50, 3283-90, (2010)

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Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner. Samit Chatterjee et al PLoS Pathog. 7, e1002378, (2011)

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Minocycline inhibition of monocyte activation correlates with neuronal protection in SIV neuroAIDS. Jennifer H. Campbell et al PLoS ONE 6, e18688, (2011)

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CAF01 potentiates immune responses and efficacy of an inactivated influenza vaccine in ferrets. Cyril Jean-Marie Martel et al PLoS ONE 6, e22891, (2011)

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Synthesis and anticancer activity of brefeldin A ester derivatives. Nwanne O Anadu et al J. Med. Chem. 49, 3897-905, (2006)

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A chemical study of cyclic depsipeptides produced by a sponge-derived fungus. Taro Amagata et al J. Nat. Prod. 69, 1560-5, (2006)

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Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

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A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole. Shaoji Cheng et al Antimicrob. Agents Chemother. 51, 1855-8, (2007)

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Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes. Julien Viaud et al Proc. Natl. Acad. Sci. U. S. A. 104, 10370-5, (2007)

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Small-molecule synergist of the Wnt/beta-catenin signaling pathway Zhang, Q. et al. Proc. Natl. Acad. Sci. U. S. A. 104, 7444-7448, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. Sabrina Schubert et al Antimicrob. Agents Chemother. 52, 4274-80, (2008)

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Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). George R Pettit et al J. Nat. Prod. 71, 438-44, (2008)

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Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Sáenz, J.B., et al. Nat. Chem. Biol., (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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Chemical biology studies on norrisolide. Gianni Guizzunti et al Bioorg. Med. Chem. 18, 2115-22, (2010)

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Merck 14,1369

Beil. 18,IV,1220