|Related Categories||A to C, Amino Acid Derivatives, Aminopeptidase, Aminopeptidase P, Antibiotics,|
Solubility testing in water at 25 mg/ml yields a clear solution. Stock solutions at 1 mM are expected to be stable at least one month stored at -20 °C.
A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.1
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microbial, ≥90% (HPLC)
microbial, ≥90% (HPLC)
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The term ‘neuropeptidases’ refers to those enzymes that participate in the inactivation of synaptically released neuropeptides and therefore serve to turn off the generated peptide signal. In general...
The effects of bestatin on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice. Lis M, Szczypka M, Suszko A, et al. Immunopharmacol. Immunotoxicol. 35(1), 133-8, (2013)
Randomized comparison of fixed-schedule versus response-oriented individualized induction therapy and use of ubenimex during and after consolidation therapy for elderly patients with acute myeloid leukemia: the JALSG GML200 Study. Wakita A, Ohtake S, Takada S, et al. Int. J. Hematol. 96(1), 84-93, (2012)
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases. Harbut MB, Velmourougane G, Dalal S, et al. Proc. Natl. Acad. Sci. U. S. A. 108(34), E526-34, (2011)
Residual dormant cancer stem-cell foci are responsible for tumor relapse after antiangiogenic metronomic therapy in hepatocellular carcinoma xenografts. Martin-Padura I, Marighetti P, Agliano A, et al. Lab. Invest. 92(7), 952-66, (2012)
Induction of specific Th1 responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Cyn d 1. Huang CF, Chu CH, Wu CC, et al. Int. Arch. Allergy Immunol. 158(2), 142-50, (2012)
Purification and characterization of porcine skeletal muscle aminopeptidase T, a novel metallopeptidase homologous to leukotriene A4 hydrolase. Sarker MA, Matsuda S, Mizutani O, et al. Biosci. Biotechnol. Biochem. 75(6), 1154-9, (2011)
Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors. Zhang X, Zhang L, Zhang J, et al. J. Enzyme Inhib. Med. Chem. 28(3), 545-51, (2013)
Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds. Tina S Skinner-Adams et al J. Med. Chem. 50, 6024-31, (2007)
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