B8416 Sigma

Bleomycin sulfate from Streptomyces verticillus

1.5-2.0 units/mg solid, BioReagent, suitable for cell culture

Synonym: Blenoxane, Bleo, Blexane

Description

Application

Recommended for use as a selection agent at 10-100 μg/ml.

Other Notes

A mixture of bleomycin sulfate salts

Biochem/physiol Actions

An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

Customers Also Viewed

Bleomycin sulfate from <I>Streptomyces verticillus</I>

crystalline, 1.5-2.0 units/mg solid

Bleomycin sulfate from <I>Streptomyces verticillus</I>

for fluorescence, mixture of bleomycin sulfate salts, lyophilized, powder, white

Etoposide

synthetic, ≥98%, powder

Neocarzinostatin from <I>Streptomyces carzinostaticus</I>

≥90% (SDS-PAGE), ~0.5 mg/mL

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?