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B8416 Sigma

Bleomycin sulfate from Streptomyces verticillus

1.5-2.0 units/mg solid, BioReagent, suitable for cell culture

Synonym: Blenoxane, Bleo, Blexane

Description

Components

This product is a mixture of glycopeptides antibiotics containing Bleomycin A2 (70%) and B2(30%). Bleomycins differ from each other in the terminal amine and show varying biological activity.

Application

Bleomycin Sulfate is an atineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.

Biochem/physiol Actions

Mode of Action: Bleomycin Sulfate binds to DNA, inhibits DNA synthesis, and causes single strand DNA scission at specific base sequences. This antibiotic can also cleave RNA, to a lesser degree but more selectively, and ats as an inducer and regulator of apoptosis and inhibits tumor angiogenesis. To cleave DNA, it is required to bind oxygen and a metal ion.

Caution

This product should be stored at 2-8°C.

Preparation Note

The product is soluble in water in water at 20 mg/mL and is active for several days. A solution of 2 units/mL in 0.1 M neutral potassium phosphate should be used within 14 days. A solution is active for three months at 3 units/mL in normal saline.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

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