B8416 Sigma

Bleomycin sulfate from Streptomyces verticillus

1.5-2.0 units/mg solid, BioReagent, suitable for cell culture

Synonym: Blenoxane, Bleo, Blexane



Recommended for use as a selection agent at 10-100 μg/ml.

Other Notes

A mixture of bleomycin sulfate salts

Biochem/physiol Actions

An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

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