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B8554 Sigma

Anti-Bax antibody, Mouse monoclonal

clone 2D2, purified from hybridoma cell culture

Synonym: Monoclonal Anti-Bax antibody produced in mouse

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies for Hematopoietic Stem Cells,
species reactivity   bovine, human
does not react with   mouse, rat
application(s)   microarray: suitable
  western blot: 1-5 μg/mL using cultured human breast adenocarcinoma MCF-7 cells, activated with dexamethasone
clone   2D2, monoclonal
concentration   ~2 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
mol wt   antigen mol wt 21 kDa (and possibly a dimer of 42 kDa)
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... BAX(581)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 3-16 of the human Bax sequence, conjugated to KLH.

General description

Bax is a tumor suppressor that belongs to the Bcl-2 family and modulates cellular apoptosis. Bax is regulated by p53 and increased Bax levels have been associated with cell death stimuli. Alterations in Bax have been linked to several neurological diseases and cancers . Monoclonal Anti-Bax antibody is specific for the epitope within amino acids 3-16 of the human Bax protein. The antibody reacts with Bax in bovines and humans, but not in mice and rats.

Physical form

Solution in phosphate bufered saline, pH 7.4, containing 15 mM sodium azide.

Application

Monoclonal Anti-Bax antibody is suitable for use in western blot (1-5 μg/mL using cultured human breast adenocarcinoma MCF-7 cells, activated with dexamethasone) and microarray.

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