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B9305 Sigma

BW 245C

≥98% (HPLC), solid

Synonym: 3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-(R*,S*)-(±)-4-imidazolineheptanioc acid

  • CAS Number 72814-32-5

  • Empirical Formula (Hill Notation) C19H32N2O5

  • Molecular Weight 368.47

  •  PubChem Substance ID 24278046

  • Popular Documents:  Datasheet (PDF)  

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   ZIDQIOZJEJFMOH-JKSUJKDBSA-N
assay   ≥98% (HPLC)
form   solid
color   off-white
solubility   DMSO: soluble10 mg/mL
originator   GlaxoSmithKline
storage temp.   −20°C
Gene Information   human ... PTGDR(5729)

Description

Biochem/physiol Actions

BW 245C was investigated for the affinities potencies, and intrinsic activities in comparison with other natural and synthetic prostanoids using endogenous receptors. The rank order of compound affinities at the DP receptor was SQ27986 (K(i) = 10 +/- 2 nM) > RS93520 = ZK110841 = BW245C (K(i) = 23-26 nM) > ZK118182 (K(i) = 50 +/- 9 nM) > PGD(2) (K(i) = 80 +/- 5 nM). DP receptor agonists produced cAMP in embryonic bovine tracheal fibroblasts with different potencies (EC(50) values in nM): ZK118182 (18 +/- 6), RS93520 (28 +/- 6), SQ27986 (29 +/- 7), ZK110841 (31 +/- 7), BW245C (53 +/- 16), and PGD(2) (98 +/- 10). BW245C was more efficacious and RS93520 was less efficacious.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Lipid Signaling Research

Within mammalian cells, a multitude of lipid compounds are found with a variety of cellular functions, including structural components of cell membranes and as second messengers in cell signaling pat...
Keywords: Absorption, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell signaling, Diabetes, Digestions, Diseases, Growth factors, Hormones, Inflammation, Lipid Metabolism, Lipid signaling, Metabolism

Peer-Reviewed Papers
15

References

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