BW 245C
≥98% (HPLC), solid
DOWNLOAD MSDS (PDF)Synonym:
3-
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CAS Number 72814-32-5
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Empirical Formula (Hill Notation) C19H32N2O5
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Molecular Weight 368.47
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PubChem Substance ID 24278046
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Popular Documents: Datasheet (PDF)
Properties
| Related Categories | Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, B, Bioactive Small Molecules, Cell Biology, |
| assay | ≥98% (HPLC) |
| form | solid |
| color | off-white |
| solubility | DMSO: soluble10 mg/mL |
| storage temp. | −20°C |
| Gene Information | human ... PTGDR(5729) |
Description
Biochem/physiol Actions
BW 245C was investigated for the affinities potencies, and intrinsic activities in comparison with other natural and synthetic prostanoids using endogenous receptors. The rank order of compound affinities at the DP receptor was SQ27986 (K(i) = 10 +/- 2 nM) > RS93520 = ZK110841 = BW245C (K(i) = 23-26 nM) > ZK118182 (K(i) = 50 +/- 9 nM) > PGD(2) (K(i) = 80 +/- 5 nM). DP receptor agonists produced cAMP in embryonic bovine tracheal fibroblasts with different potencies (EC(50) values in nM): ZK118182 (18 +/- 6), RS93520 (28 +/- 6), SQ27986 (29 +/- 7), ZK110841 (31 +/- 7), BW245C (53 +/- 16), and PGD(2) (98 +/- 10). BW245C was more efficacious and RS93520 was less efficacious.
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