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B9553 Sigma

Monoclonal Anti-Bone Morphogenetic Protein 2 antibody produced in mouse

clone 65529.111, purified immunoglobulin, lyophilized powder

Synonym: Anti-BMP-2

Description

Immunogen

recombinant human BMP-2.

General description

Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. Among the BMPs, BMP-2 has bone and cartilage inducing abilities. The other important functions of BMP-2 are in heart formation. BMP-2 signaling also involves active cross talk with major pathways such as Smad, MAPK, PI3K and NF-κ B.. Monoclonal Anti-BMP-2 recognizes recombinant BMP-2. It also detects BMP-4 (25% cross reactivity).

Physical form

Lyophilizd from a 0.2 μm filtered solution in PBS, pH 7.4, with 5% trehalose.

Specificity

The antibody recognizes recombinant human BMP-2. It shows approximately 25% cross-reactivity with recombinant human BMP-4.

Preparation Note

Purified using protein G.

Application

Monoclonal Anti-BMP-2 antibody may be used in immunoblotting at a working antibody concentration of 1-2 μg/ml.

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