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C0128 Sigma

α-Chloralose

Synonym: 1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose, Anhydro-D-glucochloral, Chloralose

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Properties

Related Categories Carbohydrate Chemistry, Carbohydrate Derivatives, Chemical Biology, Chemical Synthesis, Core Bioreagents,
impurities   ≤20% β-anomer
solubility   ethanol: soluble10 mg/mL, clear to slightly hazy, colorless to faintly yellow (or yellow-brown)

Description

Application

Used as an anesthetic for laboratory animals

Packaging

1 kg in poly bottle

25, 100, 500 g in poly bottle

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
16-24/25-28
WGK Germany 
1
RTECS 
FM9450000

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

A review of laboratory animal anesthesia with chloral hydrate and chloralose. Silverman, J. and Muir, W.W. Lab. Anim. Sci. 43, 210, (1993)

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Isoflurane anesthesia is a valuable alternative for alpha-chloralose anesthesia in the forepaw stimulation model in rats. Sommers MG, van Egmond J, Booij LH, et al. NMR Biomed. 22(4), 414-8, (2009)

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Magnetic resonance imaging quantification of regional cerebral blood flow and cerebrovascular reactivity to carbon dioxide in normotensive and hypertensive rats. Leoni RF, Paiva FF, Henning EC, et al. Neuroimage 58(1), 75-81, (2011)

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Alpha-chloralose as a canine anesthetic. Holzgrefe HH, Everitt JM, and Wright EM Lab. Anim. Sci. 37(5), 587-95, (1987)

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Neurovascular uncoupling under mild hypoxic hypoxia: an EEG-fMRI study in rats. Sumiyoshi A, Suzuki H, Shimokawa H, et al. J. Cereb. Blood Flow Metab. 32(10), 1853-8, (2012)

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Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex. Lei H, Duarte JM, Mlynarik V, et al. J. Neurosci. Res. 88(2), 413-9, (2010)

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Exercise changes regional vascular control by commissural NTS in spontaneously hypertensive rats. Ogihara CA, Schoorlemmer GH, Levada AC, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299(1), R291-7, (2010)

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The current functional state of local neuronal circuits controls the magnitude of a BOLD response to incoming stimuli. Angenstein F, Krautwald K, and Scheich H Neuroimage 50(4), 1364-75, (2010)

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Comparison of alpha-chloralose, medetomidine and isoflurane anesthesia for functional connectivity mapping in the rat. Williams KA, Magnuson M, Majeed W, et al. Magn. Reson. Imaging 28(7), 995-1003, (2010)

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Body and brain temperature coupling: the critical role of cerebral blood flow. Zhu M, Ackerman JJ, and Yablonskiy DA J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 179(6), 701-10, (2009)

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Intracortical microcirculatory change induced by anesthesia in rat somatosensory cortex. Masamoto K, Obata T, and Kanno I Adv. Exp. Med. Biol. 662, 57-61, (2010)

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Effects of isoflurane and alpha-chloralose anesthesia on BOLD fMRI responses to ingested L-glutamate in rats. Tsurugizawa T, Uematsu A, Uneyama H, et al. Neuroscience 165(1), 244-51, (2010)

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Cardiovascular responses to hydrogen peroxide into the nucleus tractus solitarius. Cardoso LM, Colombari DS, Menani JV, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297(2), R462-9, (2009)

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Low frequency stimulation of the perforant pathway generates anesthesia-specific variations in neural activity and BOLD responses in the rat dentate gyrus. Krautwald K and Angenstein F J. Cereb. Blood Flow Metab. 32(2), 291-305, (2012)

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Motion-artifact-free in vivo imaging utilizing narcotized avian embryos in ovo. Heidrich A, Würbach L, Opfermann T, et al. Mol. Imaging Biol. 13(2), 208-14, (2011)

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Differential effects of anesthetics on cocaine's pharmacokinetic and pharmacodynamic effects in brain. Du C, Tully M, Volkow ND, et al. Eur. J. Neurosci. 30(8), 1565-75, (2009)

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Distribution of chloralose in a fatal intoxication. Gerace E, Ciccotelli V, Rapetti P, et al. J. Anal. Toxicol. 36(6), 452-6, (2012)

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Vasomotion and neurovascular coupling in the visual thalamus in vivo. Rivadulla C, de Labra C, Grieve KL, et al. PLoS ONE 6(12), e28746, (2011)

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Synthesis and antimicrobial activities of two novel amino sugars derived from chloraloses. Yenil N, Ay E, Ay K, et al. Carbohydr. Res. 345(11), 1617-21, (2010)

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On the use of α-chloralose for repeated BOLD fMRI measurements in rats. Alonso Bde C, Makarova T, and Hess A J. Neurosci. Methods 195(2), 236-40, (2011)

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State-dependent amygdala stimulation-induced cardiovascular effects in rats. Chiou RJ, Kuo CC, Liang KC, et al. Chin. J. Physiol. 52(6), 432-40, (2009)

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The role of nitrite in neurovascular coupling. Piknova B, Kocharyan A, Schechter AN, et al. Brain Res. 1407, 62-8, (2011)

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Respiratory and cardiovascular effects of biphalin in anaesthetized rats. Wojciechowski P, Szereda-Przestaszewska M, and Lipkowski AW Eur. J. Pharmacol. 602(1), 50-3, (2009)

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Remote pharmacological preconditioning on median nerve territory increases Hsp32 expression and attenuates ischemia-reperfusion injury in rat heart. Chiu JH, Cheng YF, Wang JY, et al. Life Sci. 90(17-18), 629-36, (2012)

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Cocaine-induced Fos expression is detectable in the frontal cortex and striatum of rats under isoflurane but not alpha-chloralose anesthesia: implications for FMRI. Kufahl PR, Pentkowski NS, Heintzelman K, et al. J. Neurosci. Methods 181(2), 241-8, (2009)

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The Knoevenagel-Doebner reaction on 1,2-O-(2,2,2-trichloroethylidene) derivatives of D-gluco- and D-manno-furanose. Kök G, Karayıldırım T, Ay K, et al. Molecules 15(11), 7724-31, (2010)

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Different effects of α-chloralose on spontaneous and evoked GABA release in rat hippocampal CA1 neurons. Matsuura T, Iwata S, Shin MC, et al. Brain Res. Bull. 85(3-4), 180-8, (2011)

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The pharmacology of chloralose. A review. Balis GU and Monroe RR Psychopharmacology 6(1), 1-30, (1964)

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Pharmacology and toxicology of alpha chloralose: a review. Lees P Vet. Rec. 91(14), 330-3, (1972)

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Merck 14,2072

Beil. 19,IV,4906

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