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C0231 Sigma

Anti-phospho-Cdk1 (pThr14/pTyr15) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Cell Cycle, Antibodies for Kinase/Phosphatase Biology,
species reactivity   rat, mouse, human
application(s)   immunoprecipitation: 1:100
  western blot: 1:1,000
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... CDC2(983)
mouse ... Cdc2a(12534)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic phosphopeptide derived from the region of the human cdk (cyclin-dependent kinases) that contains threonine 14 and tyrosine 15.

General description

Cdk1 is a regulatory protein that stimulates mitosis in eukaryotic cells. Phosphorylation of Thr14 and Tyr15 residues in Cdk1 causes its inactivation, which eventually results in the exit of cells from the mitotic cycle. Cdk1 may also be in involved in protein SUMOylation during cell cycle regulation . Anti-phospho-Cdk1 (p(Thr14)/p(Tyr15)) antibody is specific for rat, human and mouse Cdk1 (p(Thr14)/p(Tyr15)) and other cyclin-dependent kinases that are phosphorylated on these amino acid residues. The antibody does not bind with Cdk6 or Cdk4.

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), containing 50% glycerol with 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.

Application

Anti-phospho-Cdk1 (p(Thr14)/p(Tyr15)) antibody is suitable for use in western blot (1:1,000), immunoblot (35kDa) and immunoprecipitation (1:100).

Price and Availability


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