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C0253 Sigma

Chlorambucil

Synonym: 4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutyric acid

  • CAS Number 305-03-3

  • Empirical Formula (Hill Notation) C14H19Cl2NO2

  • Molecular Weight 304.21

  •  Beilstein Registry Number 999011

  •  EC Number 206-162-0

  •  MDL number MFCD00021783

  •  PubChem Substance ID 24278287

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Description

Biochem/physiol Actions

Chlorambucil is an anti-cancer drug that alkylates DNA and induces apoptosis. Death of chronic lymphocytic leukemia cells occurs via a p53-dependent mechanism.

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Flow Cytometry Instruments

All labs need water
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
ES7525000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

Determination of Water Content in Chlorambucil Using Karl Fischer Titration

The determination of water in carboxylic acids is usually straightforward provided the substances are soluble. Strong acids must be neutralized. Acetic acid and related compounds have a tendency to u...
Keywords: Esterifications, Pharmaceutical, Titrations

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DNA损伤与修复

突变与癌症的发生均包含细胞DNA损伤过程。人类细胞中的DNA每天都会由于外部(外源)和内部(内源)的代谢进程而遭受成千上百次损伤。细胞基因组的改变可能导致DNA转录过程出现错误,进而通过翻译过程影响到信号转导和细胞功能必需的蛋白质。如果有丝分裂之前这些基因组突变尚未完成修复,则还会进一步遗传给子代细胞。一旦细胞丧失了有效修复DNA损伤的能力,就可能发生三种反应:细胞衰老、细胞凋亡和细胞癌变(参见...
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Peer-Reviewed Papers
15

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