Chlorambucil

Papers

DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards. Muller, C., et al. Blood 92, 2213-2219, (1998)

---

Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Morrow, C.S., et al. J. Biol. Chem. 273, 20114-20120, (1998)

---

Bcl-2 protein expression and p53 gene mutation in chronic lymphocytic leukemia: correlation with in vitro sensitivity to chlorambucil and purine analogs. Morabito, F., et al. Haematologica 82, 16-20, (1997)

---

Chlorambucil drug resistance in chronic lymphocytic leukemia: the emerging role of DNA repair. Panasci, L., et al. Clin. Cancer Res. 7, 454-461, (2001)

---

Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

---

Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

---

A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system. Navneet Kaur et al J. Med. Chem. 51, 1393-401, (2008)

---

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

---

Synthesis and cytotoxic properties of new fluorodeoxyglucose-coupled chlorambucil derivatives. Bastien Reux et al Bioorg. Med. Chem. 16, 5004-20, (2008)

---

Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new alkylating steroidal esters. Anna I Koutsourea et al Bioorg. Med. Chem. 16, 5207-15, (2008)

---

Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines. Stefanie Libnow et al Bioorg. Med. Chem. 16, 5570-83, (2008)

---

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells. Pal Perjési et al Eur. J. Med. Chem. 43, 839-45, (2008)

---

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

---

Synthesis and biophysical characterization of chlorambucil anticancer ether lipid prodrugs. Palle J Pedersen et al J. Med. Chem. 52, 3408-15, (2009)

---

Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

---

Synthesis and evaluation of anticancer activity of 2-arylamino-6-trifluoromethyl-3-(hydrazonocarbonyl)pyridines. Valentina Onnis et al Bioorg. Med. Chem. 17, 6158-65, (2009)

---

To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines. Shervington, L. A.; et al. Eur. J. Med. Chem. 44, 2944, (2009)

---

Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

---

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

---

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

---

Assessment of chemoselective neoglycosylation methods using chlorambucil as a model. Randal D Goff et al J. Med. Chem. 53, 8129-39, (2010)

---

Design, synthesis and biological evaluation of estradiol-chlorambucil hybrids as anticancer agents. Atul Gupta et al Bioorg. Med. Chem. Lett. 20, 1614-8, (2010)

---

Synthesis of D- and L-tyrosine-chlorambucil analogs active against breast cancer cell lines. Caroline Descôteaux et al Bioorg. Med. Chem. Lett. 20, 7388-92, (2010)

---

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

---

QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations. Andrey A Toropov et al Eur. J. Med. Chem. 45, 1639-47, (2010)

---

Synthesis and biological evaluation of cyclic nitrogen mustards based on carnitine framework. Simon Leiris et al Eur. J. Med. Chem. 45, 4140-8, (2010)

---

Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design. Mark C Wenlock et al Bioorg. Med. Chem. Lett. 21, 3550-6, (2011)

---

Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

---

Merck 14,2073

Beil. 14,IV,1715