|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,|
|Gene Information||human ... CYP1A2(1544)|
Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.
Mode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step (elongation inhibition). Bacteriostatic.
Mode of Resistance: Acetylation by chloramphenicol acetyltransferase (cat gene).
1 kg in poly bottle
5, 25, 100, 500 g in poly bottle
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P201-P308 + P313|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||45|
|Safety Statements (Europe)||53-45|
|RIDADR||UN 2811 6.1 / PGIII|
1. OBJECTIVE To standardize a procedure for the determination of the enzymatic assay of Chloramphenicol Acetyltransferase.
Keywords: Enzyme activity, Enzymology, Extinction coefficient
Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. Yudong Liu et al Antimicrob. Agents Chemother. 53, 512-8, (2009)
Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. Thalmann S, Behrens M, and Meyerhof W Biochem. Biophys. Res. Commun. 435(2), 267-73, (2013)
High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin. Tobe R, Naranjo-Suarez S, Everley RA, et al. J. Biol. Chem. 288(21), 14709-15, (2013)
Single-step selection of drug resistant Acinetobacter baylyi ADP1 mutants reveals a functional redundancy in the recruitment of multidrug efflux systems. Brzoska AJ, Hassan KA, de Leon EJ, et al. PLoS ONE 8(2), e56090, (2013)
Initial treatment of Pseudomonas aeruginosa contact lens-associated keratitis with topical chloramphenicol, and effect on outcome. Bourkiza R, Kaye S, Bunce C, et al. Br. J. Ophthalmol. 97(4), 429-32, (2013)
Modulation of mitochondrial capacity and angiogenesis by red wine polyphenols via estrogen receptor, NADPH oxidase and nitric oxide synthase pathways. Duluc L, Jacques C, Soleti R, et al. Int. J. Biochem. Cell Biol. 45(4), 783-91, (2013)
Resistance of Bacteroides isolates recovered among clinical samples from a major Costa Rican hospital between 2000 and 2008 to ß-lactams, clindamycin, metronidazole, and chloramphenicol. Cordero-Laurent E, Rodríguez C, Rodríguez-Cavallini E, et al. Rev. Esp. Quimioter. 25(4), 261-5, (2012)
Rapid antimicrobial susceptibility testing by sensitive detection of precursor rRNA using a novel electrochemical biosensing platform. Halford C, Gonzalez R, Campuzano S, et al. Antimicrob. Agents Chemother. 57(2), 936-43, (2013)
Response of bacterial isolates from Antarctic shallow sediments towards heavy metals, antibiotics and polychlorinated biphenyls. Lo Giudice A, Casella P, Bruni V, et al. Ecotoxicology 22(2), 240-50, (2013)
Structural, electronic, thermodynamical and charge transfer properties of Chloramphenicol Palmitate using vibrational spectroscopy and DFT calculations. Mishra R, Srivastava A, Sharma A, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 101, 335-42, (2013)
Study on the binding of chloroamphenicol with bovine serum albumin by fluorescence and UV-vis spectroscopy. Zhang J, Chen L, Zeng B, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 105, 74-9, (2013)
Characteristics of Staphylococcus aureus small colony variant and its parent strain isolated from chronic mastitis at a dairy farm in Beijing, China. Alkasir R, Liu X, Zahra M, et al. Microb. Drug Resist. 19(2), 138-45, (2013)
Immunoaffinity column cleanup with LC/MS/MS for the determination of chloramphenicol in honey and prawns: single-laboratory validation. Mackie J, Marley E, and Donnelly C J. AOAC Int. 96(4), 910-6, (2013)
Determination of chloramphenicol residues in aquatic products using immunoaffinity column cleanup and high performance liquid chromatography with ultraviolet detection. Zhang QJ, Peng T, Chen DD, et al. J. AOAC Int. 96(4), 897-901, (2013)
Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A β-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. Stephanie Petrella et al Antimicrob. Agents Chemother. 52, 3725-36, (2008)
Aldrich MSDS 1, 364:D / Corp MSDS 1 (1), 722:C / FT-IR 2 (2), 2987:A / FT-IR 1 (2), 362:D / FT-NMR 1 (2), 1380:A / IR-Spectra (3), 1074:A / IR-Spectra (2), 939:D / NMR-Reference 2 (2), 340:B / RegBook 1 (2), 2011:G / Sax 6, 668 / Sigma FT-IR 1 (1), 634:C / Structure Index 1, 321:A:2
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