Carmustine ≥98% | Sigma-Aldrich

Properties

Related Categories	Antitumor Agents, Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Bristol-Myers Squibb, C-CH, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, D to K, DNA Intercalators and Crosslinkers, DNA Modification / Repair, DNA metabolism, Diaphorase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glutathione Reductase More...
assay	≥98%
form	(Oily liquid to amorphous solid)
mp	30 °C(lit.)
storage temp.	−20°C
Gene Information	human ... GSR(2936)

Description

Biochem/physiol Actions

Carmustine is a DNA alkylating agent causing DNA interstrand crosslinks.¹ Effective against glioma and other solid tumors.

Price and Availability

Related Papers

1. Mechanism of glutathione-mediated DNA damage by the antineoplastic agent 1,3-bis(2-chloroethyl)-N-nitrosourea. Stahl, et al. Chem. Res. Toxicol. 5, 106, (1992)

Documents

Certificate of Analysis

Safety Information

Symbol	GHS06, GHS08
Signal word	Danger
Hazard statements	H300-H350-H360
Precautionary statements	P201-P264-P301 + P310-P308 + P313
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes (Europe)	T+
Risk Statements (Europe)	45-46-60-61-28
Safety Statements (Europe)	53-22-36/37/39-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	YS2625000

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription