|Related Categories||Antitumor Agents, Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents,|
|form||(Oily liquid to amorphous solid)|
|Gene Information||human ... GSR(2936)|
Carmustine is a DNA alkylating agent causing DNA interstrand crosslinks.1 Effective against glioma and other solid tumors.
Customers Also Viewed
lyophilized powder, 3.0-20.0 units/mg protein (biuret)
ammonium sulfate suspension, 100-300 units/mg protein (biuret)
≥98% (TLC), solid
Certificate of Analysis
|Precautionary statements||P201-P264-P301 + P310-P308 + P313|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||45-46-60-61-28|
|Safety Statements (Europe)||53-22-36/37/39-45|
|RIDADR||UN 2811 6.1 / PGII|
Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription
Simple Genetic Selection Protocol For Isolation Of Overexpressed Genes That Enhance Accumulation Of Membrane-integrated Human G Protein-coupled Receptors In Escherichia Coli. Skretas, G., and Georgiou, G. Appl. Environ. Microbiol. 76, 5852-9, (2010)
DexaBEAM versus ICE salvage regimen prior to autologous transplantation for relapsed or refractory aggressive peripheral T cell lymphoma: a retrospective evaluation of parallel patient cohorts of one center. Mikesch JH, Kuhlmann M, Demant A, et al. Ann. Hematol. 92(8), 1041-8, (2013)
Sustainable release of carmustine from biodegradable poly[((D,L))-lactide-co-glycolide] nanofibrous membranes in the cerebral cavity: in vitro and in vivo studies. Tseng YY, Liao JY, Chen WA, et al. Expert Opin. Drug Deliv. 10(7), 879-88, (2013)
Primary central nervous system diffuse large B cell lymphoma transformed from orbital mucosa-associated lymphoid tissue lymphoma: complete response to combined intrathecal and systemic rituximab. Huang HC, Cheng AL, Lin CW, et al. Ann. Hematol. 92(7), 989-92, (2013)
Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling. Crabtree MJ, Brixey R, Batchelor H, et al. J. Biol. Chem. 288(1), 561-9, (2013)
Targeted nitric oxide delivery preferentially induces glioma cell chemosensitivity via altered p53 and O(6) -methylguanine-DNA methyltransferase activity. Safdar S, Payne CA, Tu NH, et al. Biotechnol. Bioeng. 110(4), 1211-20, (2013)
Loss of O⁶-methylguanine-DNA methyltransferase confers collateral sensitivity to carmustine in topoisomerase II-mediated doxorubicin resistant triple negative breast cancer cells. Raguz S, Adams C, Masrour N, et al. Biochem. Pharmacol. 85(2), 186-96, (2013)
Cytoarchitectural, behavioural and neurophysiological dysfunctions in the BCNU-treated rat model of cortical dysplasia. Inverardi F, Chikhladze M, Donzelli A, et al. Eur. J. Neurosci. 37(1), 150-62, (2013)
F2A sequence linking MGMT(P140K) and MDR1 in a bicistronic lentiviral vector enables efficient chemoprotection of haematopoietic stem cells. Maier P, Heckmann D, Spier I, et al. Cancer Gene Ther. 19(11), 802-10, (2012)
Phase II trial of 131-Iodine tositumomab with high-dose chemotherapy and autologous stem cell transplantation for relapsed diffuse large B cell lymphoma. Vose JM, Bierman PJ, Loberiza FR, et al. Biol. Blood Marrow Transplant. 19(1), 123-8, (2013)
Safety and activity of a new intensive short-term chemoimmunotherapy in HIV-positive patients with Burkitt lymphoma. Ferreri AJ, Bruno Ventre M, Donadoni G, et al. Br. J. Haematol. 159(2), 252-5, (2012)
Allogeneic stem cell transplantation for relapsed or refractory lymphoma after conditioning with BEAM/fludarabine/TBI. O'Meara A, Halter J, Heim D, et al. Biol. Blood Marrow Transplant. 19(1), 82-6, (2013)
Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression. Falahati R, Zhang J, Flebbe-Rehwaldt L, et al. Mol. Ther. 20(11), 2180-9, (2012)
Prospective study of carmustine wafers in combination with 6-month metronomic temozolomide and radiation therapy in newly diagnosed glioblastoma: preliminary results. Salmaggi A, Milanesi I, Silvani A, et al. J. Neurosurg. 118(4), 821-9, (2013)
Iodine-131 rituximab radioimmunotherapy with BEAM conditioning and autologous stem cell transplant salvage therapy for relapsed/refractory aggressive non-Hodgkin lymphoma. Kruger PC, Cooney JP, and Turner JH Cancer Biother. Radiopharm. 27(9), 552-60, (2012)
Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies. Preukschas M, Hagel C, Schulte A, et al. PLoS ONE 7(8), e43468, (2012)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?