|Related Categories||Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, C-CH, Cell Biology, Cell Signaling and Neuroscience,|
|solubility||DMSO: ≥10 mg/mL|
|storage temp.||room temp|
Cambinol is a Sirtuin (Human Silent Information Regulator) Type 1/2 Inhibitor. Sirtuins are structurally and mechanistically unrelated to HDACs Class 1 & 2 deacetylases but share many protein targets. HDAC is a large complex enzyme family involved in epigenetic-control of gene expression. Sirt2 has an IC50 equal to 59 μM.
Gene expression is governed by complex mechanisms including transcription factor binding to DNA and coordinated changes in chromatin structure. The primary protein components of chromatin are the his...
Savita Bagga, PhD.
BioFiles v7 n3, 2012, 10–16
Keywords: Acetylations, Amplification, Cancer, Cell culture, Chromatin immunoprecipitation, Cloning, DNA purification, Diseases, Gene expression, Immunoprecipitation, Indicators, Methylations, Microarray Analysis, PAGE, Polymerase chain reaction, Polymerase chain reaction - quantitative, Polymorphisms, Purification, Sequencing, Transcription, Whole genome amplification
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|EPI003||In Situ Histone Deacetylase (HDAC) Activity Fluorometric Assay Kit, 100 assays in 96 well plates|
|EPI004||Histone Deacetylase 3 (HDAC3) Activity Assay Kit, 100 assays in 96 well plates|
|EPI005||Histone Deacetylase 3 (HDAC3) Inhibitor Screening Kit, 100 assays in 96 well plates|
|EPI006||Histone Deacetylase 8 (HDAC8) Activity Assay Kit, 100 assays in 96 well plates|
|EPI007||Histone Deacetylase 8 (HDAC8) Inhibitor Screening Kit, 100 assays in 96 well plates|
|EPI008||Histone Deacetylase (HDAC) Inhibitor Set I, Set includes 6 inhibitors|
|EPI009||Histone Deacetylase (HDAC) Inhibitor Set II, Set includes 7 inhibitors|
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