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C0623 Sigma

Anti-CKMT1B (126-140) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-CKMT1, Anti-CKMT, Anti-Creatine kinase, mitochondrial 1B, Anti-UMTCK

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Properties

Related Categories Alphabetical Index, Antibodies, CI-CN, Primary Antibodies
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~47 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CKMT1B(1159)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 126-140 of human CKMT1B

General description

Creatine kinase, mitochondrial 1B is known as CKMT1B which encodes the ubiquitous mitochondrial creatine kinase (uMtCK). It belongs to creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK which is encoded by separate genes located on chromosome 15.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CKMT1B (126-140) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.

Biochem/physiol Actions

Mitochondrial creatine kinases (MtCK) play a key role in myocardial energy homeostasis along with hexokinase. It plays a central role in energy transduction. It is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier called creatine. Over expression of uMtCK in hepatocellular carcinoma (HCC) may cause hepatocarcinogenesis and is associated with highly malignant potential.

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