Synonym: COX-1, Constitutive cyclooxygenase, Prostaglandin H synthase 1, Prostaglandin endoperoxide synthase
|Related Categories||1.14.x.x Acting on paired donors with incorporation or reduction of molecular oxygen, 1.x.x.x Oxidoreductases, Application Index, Arachidonic Acid Cascade, Biochemicals and Reagents,|
|mol wt||dimer subunit mol wt 70 kDa|
|shipped in||dry ice|
|Gene Information||sheep ... COX1(808251)|
COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively expressed in almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid.
One unit consumes one nanomole of oxygen per minute at 37 °C in 0.1 M Tris-HCl buffer, pH 8, containing 100 μM arachidonate, 5 mM EDTA, 2 mM phenol, and 1 μM hematin.
Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN® 20 and 300 μM diethyldithiocarbamate.
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Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells. Wang X, Liang Y, Wang J, et al. Tumour Biol. 34(3), 1517-22, (2013)
P2X7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction. Chiao CW, da Silva-Santos JE, Giachini FR, et al. Clin. Sci. (Lond.) 125(3), 131-41, (2013)
Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. Través PG, Pimentel-Santillana M, Carrasquero LM, et al. J. Immunol. 190(8), 4226-35, (2013)
Interaction of inflammatory and anti-inflammatory responses in microglia by Staphylococcus aureus-derived lipoteichoic acid. Huang BR, Tsai CF, Lin HY, et al. Toxicol. Appl. Pharmacol. 269(1), 43-50, (2013)
Systemic α-melanocyte-stimulating hormone administration decreases arthritis-induced anorexia and muscle wasting. Gómez-SanMiguel AB, Martín AI, Nieto-Bona MP, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304(10), R877-86, (2013)
Concurrent targeting of eicosanoid receptor 1/eicosanoid receptor 4 receptors and COX-2 induces synergistic apoptosis in Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus associated non-Hodgkin lymphoma cell lines. Paul AG, Chandran B, and Sharma-Walia N Transl. Res. 161(6), 447-68, (2013)
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors. Anzini M, Di Capua A, Valenti S, et al. J. Med. Chem. 56(8), 3191-206, (2013)
Deletion of cyclooxygenase-2 in the mouse increases arterial blood pressure with no impairment in renal NO production in response to chronic high salt intake. Stæhr M, Hansen PB, Madsen K, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304(10), R899-907, (2013)
Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways. Lai WW, Hsu SC, Chueh FS, et al. Anticancer Res. 33(5), 1941-50, (2013)
Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro. Girol AP, Mimura KK, Drewes CC, et al. J. Immunol. 190(11), 5689-701, (2013)
Regulation of the angiogenesis of acquired middle ear cholesteatomas by inhibitor of DNA binding transcription factor. Fukudome S, Wang C, Hamajima Y, et al. JAMA Otolaryngol. Head Neck Surg. 139(3), 273-8, (2013)
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Ohki S, Ogino N, Yamamoto S, et al. J. Biol. Chem. 254(3), 829-36, (1979)
Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells. Bazan NG and Lukiw WJ J. Biol. Chem. 277(33), 30359-67, (2002)
Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. Jones DA, Carlton DP, McIntyre TM, et al. J. Biol. Chem. 268(12), 9049-54, (1993)
Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. Lukiw WJ, Pelaez RP, Martinez J, et al. Proc. Natl. Acad. Sci. U. S. A. 95(7), 3914-9, (1998)
Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. Scott BT, Hasstedt SJ, Bovill EG, et al. Blood Coagul. Fibrinolysis 13(6), 519-31, (2002)
Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha. Diaz A, Reginato AM, and Jimenez SA J. Biol. Chem. 267(15), 10816-22, (1992)
Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase). Takahashi Y, Ueda N, Yoshimoto T, et al. Biochem. Biophys. Res. Commun. 182(2), 433-8, (1992)
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