Synonym: COX-1, Constitutive cyclooxygenase, Prostaglandin H synthase 1, Prostaglandin endoperoxide synthase
|Related Categories||1.14.x.x Acting on paired donors with incorporation or reduction of molecular oxygen, 1.x.x.x Oxidoreductases, Application Index, Arachidonic Acid Cascade, Biochemicals and Reagents,|
|mol wt||dimer subunit mol wt 70 kDa|
|shipped in||dry ice|
|Gene Information||sheep ... COX1(808251)|
COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively expressed in almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid.
One unit consumes one nanomole of oxygen per minute at 37 °C in 0.1 M Tris-HCl buffer, pH 8, containing 100 μM arachidonate, 5 mM EDTA, 2 mM phenol, and 1 μM hematin.
Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN® 20 and 300 μM diethyldithiocarbamate.
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