Cyclooxygenase 1 from sheep
aqueous solution, ≥95% (SDS-PAGE), ≥40,000 units/mg protein
DOWNLOAD MSDS (PDF)Synonym: COX-1, Constitutive cyclooxygenase, Prostaglandin H synthase 1, Prostaglandin endoperoxide synthase
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MDL number MFCD02098124
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Popular Documents: Datasheet (PDF)
| Properties
| Related Categories | 1.14.x.x Acting on paired donors with incorporation or reduction of molecular oxygen, 1.x.x.x Oxidoreductases, Application Index, Arachidonic Acid Cascade, Biochemicals and Reagents, |
| assay | ≥95% (SDS-PAGE) |
| form | aqueous solution |
| mol wt | dimer subunit mol wt 70 kDa |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | sheep ... COX1(808251) |
Description
Biochem/physiol Actions
COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively expressed in almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid.
Unit Definition
One unit consumes one nanomole of oxygen per minute at 37 °C in 0.1 M Tris-HCl buffer, pH 8, containing 100 μM arachidonate, 5 mM EDTA, 2 mM phenol, and 1 μM hematin.
Physical form
Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN® 20 and 300 μM diethyldithiocarbamate.
Price and Availability
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