Cyclophosphamide monohydrate bulk package

Properties

Related Categories	ALDH1A, Apoptosis Reagents, Apoptosis and Cell Cycle, Bioactive Small Molecules, Breast Cancer Stem Cell Markers, CI-CY, Cancer Research, Cancer Stem Cells, Cell Biology, Cell Signaling and Neuroscience, DNA Intercalators and Crosslinkers, DNA metabolism, Other Apoptosis Related Reagents More...
assay	97.0-103.0% (HPLC)
mp	49-51 °C(lit.)
storage temp.	2-8°C
Gene Information	human ... ALDH1A1(216), ALDH1B1(219)

Description

Packaging

1, 5, 10, 25 g in glass bottle

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Price and Availability

Related Papers

Targeting The Notch1 And MTOR Pathways In A Mouse T-ALL Model. Cullion, K., et al. Blood 113, 6172-81, (2009)

Documents

Certificate of Analysis

Certificate of Origin

C0768 - Product Information Sheet (47 KB)

FT-IR Raman

FT-NMR

Safety Information

Symbol	GHS06, GHS08
Signal word	Danger
Hazard statements	H301-H350
Precautionary statements	P201-P301 + P310-P308 + P313
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes (Europe)	T
Risk Statements (Europe)	45-25
Safety Statements (Europe)	53-45
RIDADR	UN 3464 6.1/PG 3
WGK Germany	3
RTECS	RP6157750
Flash Point(F)	235.4 °F
Flash Point(C)	113 °C

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

ABC Transporters and Cancer Drug Resistance

Chemotherapy is the treatment of choice against many types of cancer. However, over time chemotherapeutic drugs can become less effective due to the development of resistance that involves a group of...
BioFiles 2007, 2.4, 7.
Keywords: Absorption, Cancer, Clinical, Cloning, Combinatorial synthesis, Diseases, Enzymology, Gene expression, Genetic, Immunology, Pharmaceutical, Reductions, Transfection

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Transcription, transformation

Papers

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Targeting The Notch1 And MTOR Pathways In A Mouse T-ALL Model. Cullion, K., et al. Blood 113, 6172-81, (2009)

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Down-regulation Of The Notch Pathway Mediated By A Gamma-secretase Inhibitor Induces Anti-tumour Effects In Mouse Models Of T-cell Leukaemia. Tammam, J., et al. Br. J. Pharmacol. 158, 1183-95, (2009)

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DNA Alkylating Therapy Induces Tumor Regression Through An HMGB1-Mediated Activation Of Innate Immunity. Guerriero, J.L., et al. J. Immunol. 186, 3517-26, (2011)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Regulation of BAX and BCL-2 expression in breast cancer cells by chemotherapy. Gibson, L.F., et al. Breast Cancer Res. Treat. 55, 107-117, (1999)

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Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein. Ren, S., et al. Drug Metab. Dispos. 27, 133-137, (1999)

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Mechanisms by which chemotherapeutic agents augment the antitumor effects of tumor necrosis factor: involvement of the pattern shift of cytokines from Th2 to Th1 in tumor lesions. Inagawa, H., et al. Anticancer Res. 18, 3957-3964, (1998)

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Merck 14,2747

Aldrich MSDS 1, 537:C / Corp MSDS 1 (1), 992:C / FT-IR 1 (1), 920:C / FT-IR 2 (1), 1582:D / FT-NMR 1 (1), 1500:B / IR-Spectra (3), 552:G / NMR-Reference 2 (2), 872:B / RegBook 1 (1), 1119:E / Sax 6, 1277 / Sigma FT-IR 1 (2), 418:D / Structure Index 1, 173:D:4