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C0832 Sigma

Clozapine N-oxide

Synonym: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide

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Description

Biochem/physiol Actions

5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

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European Pharmacopoeia (EP) Reference Standard

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
HP1760000

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

Peer-Reviewed Papers

References

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Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks. Michaelides M, Anderson SA, Ananth M, et al. J. Clin. Invest. 123(12), 5342-50, (2013)

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Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. Roth, B.L., et al. J. Pharmacol. Exp. Ther. 268, 1403, (1994)

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Decomposition of clozapine N-oxide in the qualitative and quantitative analysis of clozapine and its metabolites. Lin, G., et al. J. Pharm. Sci. 83, 1412, (1994)

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Kuoppamaki, M., et al. Eur. J. Pharmacol., Molec. Pharmacol. Sec. 245, 179, (1993)

Determination of clozapine, norclozapine, and clozapine-N-oxide in serum by liquid chromatography. Volpicelli, S.A., et al. Clin. Chem. 39, 1656, (1993)

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Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. Anderson SA, Michaelides M, Zarnegar P, et al. J. Clin. Invest. 123(12), 5334-41, (2013)

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Independent hypothalamic circuits for social and predator fear. Silva BA, Mattucci C, Krzywkowski P, et al. Nat. Neurosci. 16(12), 1731-3, (2013)

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Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. Ulrich Zachariae et al J. Med. Chem. 52, 4266-76, (2009)

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Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors. Zhong P, Liu X, Zhang Z, et al. J. Neurosci. 34(18), 6352-66, (2014)

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Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Park JS, Rhau B, Hermann A, et al. Proc. Natl. Acad. Sci. U. S. A. 111(16), 5896-901, (2014)

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