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C0875 Sigma

Calcein

Used for the fluorometric determination of calcium and EDTA titration of calcium in the presence of magnesium.

Synonym: Bis[N,N−bis(carboxymethyl)aminomethyl]fluorescein, Fluorescein-bis(methyliminodiacetic acid), Fluorexon

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Packaging

5, 10, 25 g in glass bottle

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Safety & Documentation

Safety Information

WGK Germany 
3
Protocols & Articles

Articles

ABC Transporters and Cancer Drug Resistance

Chemotherapy is the treatment of choice against many types of cancer. However, over time chemotherapeutic drugs can become less effective due to the development of resistance that involves a group of...
BioFiles 2007, 2.4, 7.
Keywords: Absorption, Cancer, Clinical, Cloning, Combinatorial synthesis, Diseases, Enzymology, Gene expression, Genetic, Immunology, Pharmaceutical, Reductions, Search, Transfection, Vectors

Sensor Dyes

In 1998 R.F. Furchgott, L.J. Ignarro, and F. Murad received the Nobel Prize in Physiology and Medicine for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular syst...
Monika Baeumle
BioFiles 2011, 6.3, 23.
Keywords: Applications, Biochemistry, Biological processes, Cancer, Cardiovascular, Central Nervous System, Diseases, Extinction coefficient, Indicators, Inflammation, Methods, Microscopy, Neurotransmission, Sol-gel, Type

Peer-Reviewed Papers

References

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Wallach, D.F.H., et al. Anal. Chem. 31, 456, (1959)

Bone Density, Strength, And Formation In Adult Cathepsin K (-/-) Mice. Pennypacker, B., et al. Bone 44, 199-207, (2009)

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Myelosuppressive therapies significantly increase pro-inflammatory cytokines and directly cause bone loss. Quach JM, Askmyr M, Jovic T, et al. J. Bone Miner Res. 30(5), 886-97, (2015)

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Extracellular matrix mineralization in murine MC3T3-E1 osteoblast cultures: an ultrastructural, compositional and comparative analysis with mouse bone. Addison WN, Nelea V, Chicatun F, et al. Bone 71, 244-56, (2014)

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A novel fragment based strategy for membrane active antimicrobials against MRSA. Li J, Liu S, Koh JJ, et al. Biochim. Biophys. Acta 1848(4), 1023-31, (2015)

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microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2. Zuo B, Zhu J, Li J, et al. J. Bone Miner Res. 30(2), 330-45, (2015)

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CXCL1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space. Vries MH, Wagenaar A, Verbruggen SE, et al. Angiogenesis 18(2), 163-71, (2015)

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Synergistic activity of the tyrocidines, antimicrobial cyclodecapeptides from Bacillus aneurinolyticus, with amphotericin B and caspofungin against Candida albicans biofilms. Troskie AM, Rautenbach M, Delattin N, et al. Antimicrob. Agents Chemother. 58(7), 3697-707, (2014)

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Altered FoF1 ATP synthase and susceptibility to mitochondrial permeability transition pore during ischaemia and reperfusion in aging cardiomyocytes. Fernandez-Sanz C, Ruiz-Meana M, Castellano J, et al. Thromb. Haemost. 113(3), 441-51, (2015)

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Hybrid multiphoton volumetric functional imaging of large-scale bioengineered neuronal networks. Dana H, Marom A, Paluch S, et al. Nat. Commun. 5, 3997, (2014)

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Membrane interactions and biological activity of antimicrobial peptides from Australian scorpion. Luna-Ramírez K, Sani MA, Silva-Sanchez J, et al. Biochim. Biophys. Acta 1838(9), 2140-8, (2014)

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The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice. Artsi H, Cohen-Kfir E, Gurt I, et al. Endocrinology 155(9), 3508-15, (2014)

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Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells. Blüml S, Friedrich M, Lohmeyer T, et al. Ann. Rheum. Dis. 74(1), 227-33, (2014)

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Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles. Dmitriev RI, Borisov SM, Kondrashina AV, et al. Cell. Mol. Life Sci. 72(2), 367-81, (2015)

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Direct and stereospecific interaction of amphidinol 3 with sterol in lipid bilayers. Espiritu RA, Matsumori N, Tsuda M, et al. Biochemistry 53(20), 3287-93, (2014)

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Aspect ratio plays a role in the hazard potential of CeO2 nanoparticles in mouse lung and zebrafish gastrointestinal tract. Lin S, Wang X, Ji Z, et al. ACS Nano 8(5), 4450-64, (2014)

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Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor. Schönfeld K, Sahm C, Zhang C, et al. Mol. Ther. 23(2), 330-8, (2015)

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Novel EP4 receptor agonist-bisphosphonate conjugate drug (C1) promotes bone formation and improves vertebral mechanical properties in the ovariectomized rat model of postmenopausal bone loss. Liu CC, Hu S, Chen G, et al. J. Bone Miner Res. 30(4), 670-80, (2015)

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ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease. Hayes M, Gao X, Yu LX, et al. Nat. Commun. 5, 4777, (2014)

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Modified-chitosan/siRNA nanoparticles downregulate cellular CDX2 expression and cross the gastric mucus barrier. Sadio A, Gustafsson JK, Pereira B, et al. PLoS ONE 9(6), e99449, (2014)

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Stimulation of bone growth following zinc incorporation into biomaterials. Qiao Y, Zhang W, Tian P, et al. Biomaterials 35(25), 6882-97, (2014)

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Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats. Grubbe MC, Thomsen JS, Nyengaard JR, et al. J. Musculoskelet. Neuronal Interact. 14(4), 473-83, (2014)

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Decellularized cartilage-derived matrix as substrate for endochondral bone regeneration. Gawlitta D, Benders KE, Visser J, et al. Tissue Eng. Part A 21(3-4), 694-703, (2015)

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Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. Kitaura Y, Hojo H, Komiyama Y, et al. PLoS ONE 9(10), e109597, (2014)

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Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis. Arioka M, Takahashi-Yanaga F, Sasaki M, et al. Biochem. Pharmacol. 90(4), 397-405, (2014)

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Tissue engineering of a vascularized bone graft of critical size with an osteogenic and angiogenic factor-based in vivo bioreactor. Liu Y, Möller B, Wiltfang J, et al. Tissue Eng. Part A 20(23-24), 3189-97, (2014)

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Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions. Raman R, Allen SP, Goodall EF, et al. Neuropathol. Appl. Neurobiol. 41(2), 201-26, (2015)

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Self-assembling dual component nanoparticles with endosomal escape capability. Wong AS, Mann SK, Czuba E, et al. Soft Matter 11(15), 2993-3002, (2015)

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Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics. Maas SL, de Vrij J, van der Vlist EJ, et al. J. Control. Release 200, 87-96, (2015)

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Endochondral bone formation in gelatin methacrylamide hydrogel with embedded cartilage-derived matrix particles. Visser J, Gawlitta D, Benders KE, et al. Biomaterials 37, 174-82, (2015)

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Persistence of CTL clones targeting melanocyte differentiation antigens was insufficient to mediate significant melanoma regression in humans. Chandran SS, Paria BC, Srivastava AK, et al. Clin. Cancer Res. 21(3), 534-43, (2015)

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Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation. Russell PK, Clarke MV, Cheong K, et al. J. Bone Miner Res. 30(5), 809-23, (2015)

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Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma. Pandey V, Wu ZS, Zhang M, et al. Breast Cancer Res. 16(5), 429, (2014)

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Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia. Gomez-Rodriguez V, Orbe J, Martinez-Aguilar E, et al. FASEB J. 29(3), 960-72, (2015)

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Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression. Almahariq M, Mei FC, Wang H, et al. Biochem. J. 465(2), 295-303, (2015)

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Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model. Reagan MR, Mishima Y, Glavey SV, et al. Blood 124(22), 3250-9, (2014)

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mTORC2 signaling promotes skeletal growth and bone formation in mice. Chen J, Holguin N, Shi Y, et al. J. Bone Miner Res. 30(2), 369-78, (2015)

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PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. Qiu T, Xian L, Crane J, et al. J. Bone Miner Res. 30(2), 309-17, (2015)

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Development, validation and characterization of a novel mouse model of Adynamic Bone Disease (ABD). Ng AH, Willett TL, Alman BA, et al. Bone 68, 57-66, (2014)

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Loss of Runx2 in committed osteoblasts impairs postnatal skeletogenesis. Adhami MD, Rashid H, Chen H, et al. J. Bone Miner Res. 30(1), 71-82, (2014)

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Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts. Amend SR, Uluckan O, Hurchla M, et al. J. Bone Miner Res. 30(1), 106-15, (2014)

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CXCL12/stromal-cell-derived factor-1 effectively replaces endothelial progenitor cells to induce vascularized ectopic bone. Eman RM, Hoorntje ET, Öner FC, et al. Stem Cells Dev. 23(24), 2950-8, (2014)

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Targeting methicillin-resistant Staphylococcus aureus with short salt-resistant synthetic peptides. Mohamed MF, Hamed MI, Panitch A, et al. Antimicrob. Agents Chemother. 58(7), 4113-22, (2014)

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P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. Bleier BS, Nocera AL, Iqbal H, et al. Int. Forum Allergy Rhinol. 4(6), 488-94, (2014)

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BMP-2 encapsulated polysaccharide nanoparticle modified biphasic calcium phosphate scaffolds for bone tissue regeneration. Wang Z, Wang K, Lu X, et al. J. Biomed. Mater. Res. A 103(4), 1520-32, (2015)

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Engineering cellular response using nanopatterned bulk metallic glass. Padmanabhan J, Kinser ER, Stalter MA, et al. ACS Nano 8(5), 4366-75, (2014)

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Androgens inhibit the osteogenic response to mechanical loading in adult male mice. Sinnesael M, Laurent MR, Jardi F, et al. Endocrinology 156(4), 1343-53, (2015)

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Cholesterol stimulates and ceramide inhibits Sticholysin II-induced pore formation in complex bilayer membranes. Alm I, García-Linares S, Gavilanes JG, et al. Biochim. Biophys. Acta 1848(4), 925-31, (2015)

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Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts. Shin NY, Choi H, Neff L, et al. J. Cell Biol. 207(1), 73-89, (2014)

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