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C0996 Sigma

cDPCP

≥98% (HPLC), solid

Synonym: Pyriplatin, cis-Diammine(pyridine)chloroplatinum(II) chloride, cis-[Pt(NH3)2(py)Cl]+ chloride

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology,
InChI Key   JDWBOMGRVMIMAU-UHFFFAOYSA-L
assay   ≥98% (HPLC)
form   solid
color   white to off-white
solubility   H2O: >10 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent. It is a cationic monofunctional platinum(II) complex with unique chemical and biological properties. cDPCP binds covalently only to a single DNA base (the N7 atom of a single guanosine residue), and thus forms monofunctional rather than bifunctional lesions with DNA. cDPCP effectively blocks transcription from DNA templates carrying adducts of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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