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C1103 Sigma

Anti-Calcium Channel (α1 Subunit), Pan antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
species reactivity   rat, mouse
application(s)   immunohistochemistry: suitable using rat heart sections
  western blot: 1:200 using rat brain membranes
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Cacna1c(12288)
rat ... Cacna1c(24239)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 1506-1524 of the α1S subunit of rat skeletal muscle voltage-gated calcium channel (VGCC, CP15) (Accession P22002) with additional N-terminal cysteine, conjugated to MBS-KLH.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide.

Specificity

The epitope recognized by this antibody is masked by α2 and δ chains; therefore, the antibody binds only after subunit dissociation using Triton X-100 or other detergents.

Application

Anti-Calcium Channel (α1 Subunit), Pan antibody produced in rabbit is suitable for immunohistochemistry (using rat heart sections) and western blotting at a dilution of 1:200 using rat brain membranes.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Biochem/physiol Actions

Calcium channel, voltage-dependent, L type, α1C subunit (Cav1.2) is a protein encoded by the CACNA1C gene in humans and belongs to the family of voltage-gated calcium channels. It serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate different physiological events. CACNA1C is a subunit of L-type voltage-dependent calcium channel. It is mapped to chromosome 12p13.3 and is implicated as a susceptibility gene for schizophrenia. CACNA1C is selectively expressed in human TH2 cells and blockage of Cav1.2 channel activation in TH2 cells may represent new strategies to treat allergic diseases in human subjects. Its increased activity is implicated in the pathogenesis of dementia and Alzheimer′s disease (AD).

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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

Articles

Antihypertensive Agents

Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions

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Peer-Reviewed Papers
15

References

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